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Combined hyperlipidemia



Combined hyperlipidemia
Classification & external resources
ICD-10 E78.4
ICD-9 272.4

In medicine, combined hyperlipidemia (or -aemia) is a commonly occurring form of hypercholesterolemia (elevated cholesterol levels) characterised by increased LDL and triglyceride concentrations, often accompanied by decreased HDL. On lipoprotein electrophoresis (a test now rarely performed) it shows as a hyperlipoproteinemia type IIB.

Additional recommended knowledge

The elevated triglyceride levels (>5 mmol/l) are generally due to an increase in VLDL (very low density lipoprotein), a class of lipoprotein that is prone to cause atherosclerosis.

Types

There are roughly two forms of this lipid disorder:

Treatment

Both conditions are treated with fibrate drugs, which act on the peroxisome proliferator-activated receptors (PPARs), specifically PPARα, to decrease free fatty acid production.

Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin) can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor expression.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Combined_hyperlipidemia". A list of authors is available in Wikipedia.
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