To use all functions of this page, please activate cookies in your browser.
my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Stevens-Johnson syndrome
Stevens-Johnson syndrome (SJS) is a severe and life-threatening condition. It is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. There is agreement in the medical literature that Stevens-Johnson syndrome can be considered a milder form of toxic epidermal necrolysis (TEN). However, there is debate whether it falls on a spectrum of disease that includes erythema multiforme;[1][2] many consider erythema multiforme (EM) to be unrelated to SJS and TEN.[3][4] Some classify SJS as a severe expression of erythema multiforme, and it occasionally referred to as erythema multiforme major.[citation needed] Additional recommended knowledge
EpidemiologySJS is a rare condition, with a reported incidence of around one case per million people per year. CausesSJS can be caused by infections (usually following viral infections such as herpes simplex virus, influenza, mumps, cat-scratch fever, histoplasmosis, Epstein-Barr virus, or similar), allergic reactions to drugs, (Dicloflex, fluconazole,[5] valdecoxib, penicillins, barbiturates, sulfas, phenytoin, lamotrigine, nevirapine, Ibuprofen, ethosuximide, carbamazepine)[6][7], malignancy (carcinomas and lymphomas), or idiopathic factors (up to 50% of the time). SJS has also been consistently reported as an uncommon side effect of herbal supplements containing ginseng. SJS may also be caused by cocaine usage.[8] [Images"http://www.inbound.ch/anabel/home.htm"][1] TreatmentDiscontinue all medications, particularly those known to cause SJS reactions. Treatment is initially similar to that of patients with thermal burns, and continued care can only be supportive (e.g. IV fluids) and symptomatic (e.g. analgesic mouth rinse for mouth ulcer); there is no specific drug treatment (2002). Treatment with corticosteroids is controversial since it might aggravate the condition or increase risk of secondary infections. Other agents have been used, including cyclophosphamide and cyclosporine, but none have exhibited much therapeutic success. Intravenous immunoglobulin (IVIG) treatment has shown some promise in reducing the length of the reaction and improving symptoms. Other common supportive measures include the use of topical pain anesthetics and antiseptics, maintaining a warm environment, and intravenous analgesics. An ophthalmologist should be consulted immediately, as SJS frequently causes the formation of scar tissue inside the eyelids leading to corneal vascularization and impaired vision, as well as a host of other ocular problems. Also, an extensive physical therapy program ensues after the patient is discharged from the hospital
PrognosisSJS proper (with less than 10% of body surface area involved) has the mortality rate of around 5%. The risk for death can be estimated using the SCORTEN scale, which takes a number of prognostic indicators into account.[8] Other outcomes include organ damage and blindness. EponymIt is named for Albert Stevens and Frank Johnson.[9][10] People with Stevens-Johnson Syndrome
References
|
|||||||||||||||||||||||||||||||||
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Stevens-Johnson_syndrome". A list of authors is available in Wikipedia. |
- Optimisation des procédures d'édition du génome - Des scientifiques parviennent à renforcer l'efficacité de CRISPR/Cas9 et des méthodes connexes et à modifier des séquences d'ADN initialement inaccessibles
- Operon
- Brood_parasite
- Category:Anatomy
- AI-enabled imaging of retina’s vascular network can predict cardiovascular disease and death - Paves way for accurate non-invasive screening test that doesn’t have to be done in clinic