UK biotech firm
Avidex today announced that it has licensed
exclusive rights to develop products recognising a proprietary antigen associated with
type 1
diabetes from
King's College London (KCL). Avidex will develop one of its soluble
monoclonal T cell receptors (mTCRs) to target KCL's antigen on the islet cells in the
pancreas.
The antigen, which is highly expressed on such cells, was discovered by researchers at
KCL and is thought to be present in a substantial proportion of patients with type I diabetes,
making it an extremely attractive target for the development of diabetes therapies.
Avidex's mTCR
protein therapy which targets this antigen is called HiDex® and is in pre-clinical
research. HiDex® is a fusion protein of the specific mTCR and a cytokine known to be a
potent immunomodulator. It is designed to down-regulate the autoimmune response that destroys
insulin producing cells within the pancreas at the onset of diabetes with the aim of maintaining
islet cell function. If successful this will preclude or reduce the need for patients to
administer recombinant insulin. Soluble mTCRs offer the best approach for targeting this
antigen as it is from an intracellular protein and TCRs are able to bind such
antigens.
The licensing agreement brings together for the first time the leading research of Professor
Mark Peakman of King's College London, who is investigating the role of antigens in type
1 diabetes, and Avidex's expertise in generating highly specific soluble T cell receptors.
Avidex uses phage display to engineer mTCRs able to bind the target with sufficiently high
affinity to become useful therapeutically.
Dr Neill Moray MacKenzie, Chief Business Officer at Avidex, said, "While targeted immunotherapeutic
approaches are being investigated as novel therapies in type 1 diabetes in academia, and
to a lesser extent industry, until now there have been no immunotherapeutic approaches
for diabetes using targets that may allow the specific protection of islet cells. Avidex's
mTCR technology is the only approach that allows targeted antigen specific suppression
of autoimmune T cell responses. This new approach brings the hope of altering the progression
and treatment of this serious disease and represents a new indication for Avidex, expanding
our pipeline in
autoimmune diseases."
Professor Peakman agrees. "The mTCR technology that Avidex can bring to the field of type
1 diabetes is unique in targeting immune modulation to the islets, where it is needed.
Combined with the right antigens, there is every expectation of translating this into a
powerful therapeutic."
Dr MacKenzie added, "Professor Peakman and his colleagues at King's College London are
leading authorities on diabetes associated antigens and we are delighted to announce this
opportunity to work with them."
Professor Peakman is equally enthusiastic; "The prospect of working with Avidex is an exciting
one. Their's is cutting edge technology that has a very real prospect of future translation
into therapeutics for type 1 diabetes."
Dr Angela Wilson, Director of Research at Diabetes UK said, "We are delighted that Avidex
has bought a licence to help develop this groundbreaking research. This is a prime example
of how the investment of Diabetes UK has taken research from the laboratory to a stage
where it has real potential to make a difference to people with diabetes. We are tremendously
excited by this."
* Professor Peakman's research is supported by Diabetes UK and the Wellcome Trust