Increasing Dynamic Binding Capacity of Oligo dT for mRNA Purification
From Screening of Chromatographic Conditions to Scale-up
This document from Sartorius BIA Separations presents a study on optimizing dynamic binding capacity (DBC) for purifying therapeutic mRNA using affinity chromatography. Researchers used the CIM Oligo dT Well Plate for multi-parallel screening to quickly identify key factors affecting binding conditions.
The results show that with proper optimization, a dynamic binding capacity exceeding 6 mg/mL can be achieved and reliably scaled up to preparative chromatographic columns. This approach significantly reduces development time and supports faster, more efficient scale-up of mRNA purification processes.
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Increasing Dynamic Binding Capacity of Oligo dT for mRNA Purification
From Screening of Chromatographic Conditions to Scale-up
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