Flexible Scaling of Protein Purification with Magnetic Beads

The scalability of protein purification is crucial for researchers involved in process development, since it allows them to seamlessly transition from laboratory-scale experiments to large-scale production, even for industrial applications.

Magnetic bead-based purification is highly scalable, making it suitable for processing a wide range of sample volumes. The process can be adapted to different sample sizes, from small-scale high-throughput screenings to large-scale protein production, depending on the application.

However, high costs and loss of performance for large volumes are factors that raise concerns for the applicability of magnetic bead-based protein isolation for such a transition.

Here, we present a time-saving magnetic bead workflow that offers high purity and yield regardless of increasing sample volumes, enables efficient bead regeneration, and thus significantly reduces time and costs.