Dharmacon to deliver First Whole Human Genome-Wide siRNA Library

18-May-2005

Dharmacon, Inc. announced an agreement to deliver a genome-wide short-interfering RNA (siRNA) library covering approximately 22.000 human genes to Millennium Pharmaceuticals, Inc. This library, the first siRNA collection targeting genes across the entire human genome, was developed using Dharmacon's proprietary SMARTselectionTM and SMARTpool® technologies. The resulting siRNA library will enable high-throughput functional genomic studies designed to identify and validate novel drug targets.

"Dharmacon's development of the first human-genome-wide siRNA libray is a significant step forward in facilitating the use of RNA interference as a major drug-discovery tool," said Leland Foster, president and chief executive officer of the Biosciences group of Fisher Scientific International Inc., which includes Dharmacon. "Millennium has a well-established history of scientific leadership and innovation in drug discovery, and we are proud the Millennium researchers have chosen Dharmacon's advanced gene-silencing technologies for use in their drug-discovery and target-validation programs."

Dharmacon's siARRAY® siRNA libraries are powerful tools for rapidly analyzing entire gene families and pathways or for conducting unbiased screens of thousands of potential drug targets. SMARTpool siRNA reagents, innovative mixtures of four highly functional siRNAs, provide potent gene silencing while minimizing off-target effects and reducing the likelihood of false-positive and false-negative results, important considerations when used in high-throughput-screening applications. This consistent high level of performance is enabling a wide variety of novel biological studies, including applications in drug discovery and development.

https://www.bionity.com/en/news/46008/dharmacon-to-deliver-first-whole-human-genome-wide-sirna-library.html