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Classification & external resources
ICD-10 M79.3
ICD-9 729.3
DiseasesDB 29081
MeSH D015434

Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous fatty and muscle tissue. Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue.




It can occur in any fatty tissue (cutaneous or visceral) and is often diagnosed on the basis of a deep skin biopsy, and can be further classified by histological characteristics based on the location of the inflammatory cells (within fatty lobules or in the septa which separate them) and on the presence or absence of vasculitis.

There are thus four main histological subtypes:

  1. lobular panniculitis without vasculitis (acute panniculitis, previously termed Weber-Christian disease [1], systemic nodular panniculitis)
  2. lobular panniculitis with vasculitis
  3. septal panniculitis without vasculitis
  4. septal panniculitis with vasculitis


Panniculitis can also be classified based on the presence or absence of systemic symptoms:

Associated conditions

Lipoatrophy (the loss of subcutaneous tissue) can occur in any of these conditions.

See also

  • DermAtlas -639418194
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Panniculitis". A list of authors is available in Wikipedia.
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