UCB and Domainex Collaboration Provides Valuable Information on Cancer Drug Target
Combinatorial domain hunting technology aids identification of MEK protein suitable for structure-based drug discovery
The key step in this work, reported in the latest edition of the Journal of Structural Biology, used Domainex’s Combinatorial Domain Hunting (CDH) technology to identify a form of the MEK protein which can be produced in large quantities and which is suitable for structure-based drug discovery. In the case of MEK, this was challenging because conventional methods proved unsuccessful, however Domainex’s CDH technology allowed the problem to be solved rapidly.
“The partnership with Domainex has been invaluable for our MEK discovery program. Successful collaborations, such as this, are a key part of UCB’s innovative and cutting-edge research. We hope that the novel class of MEK inhibitors which the UCB team discovered will bring benefits to patients,” said Neil Weir, Senior Vice President, Discovery Research UCB.
Original publication
Meier C, Brookings DC, Ceska TA, Doyle C, Gong H, McMillan D, Saville GP et al.; "Engineering human MEK for structural studies: A case study of combinatorial domain hunting.", Journal of Structural Biology (2012); 177:329-34.
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Original publication
Meier C, Brookings DC, Ceska TA, Doyle C, Gong H, McMillan D, Saville GP et al.; "Engineering human MEK for structural studies: A case study of combinatorial domain hunting.", Journal of Structural Biology (2012); 177:329-34.
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