Identifying pathogens within minutes instead of days
Mass spectrometry detects bacteria without time-consuming isolation and multiplication
Speed and reliability are crucial in the diagnosis of diseases. Researchers at the Technical University of Munich (TUM) and Imperial College London have developed a new method to identify bacteria with unprecedented speed. This means that the waiting time can be reduced from several days to just a few minutes.
Traditionally, bacterial diseases are diagnosed by the tedious isolation of pathogens and the creation of bacterial cultures. Waiting times of several days are the rule here. Only then can the targeted treatment of the disease begin. The team led by Nicole Strittmatter, Professor of Analytical Chemistry at TUM, and Dr. James S. McKenzie (Imperial) uses mass spectrometry for its innovative approach. This enabled the researchers to identify specific metabolic products of bacteria directly in tissue and stool samples.
At the heart of the process is a database in which 232 medically important bacterial species and their metabolic products have been recorded to date. Biomarkers are derived from this database, which can then be used to directly detect specific bacteria. Among the bacteria that can be identified using the new method are clinically extremely important pathogens that can, for example, trigger stomach cancer, are responsible for certain pneumonias and meningitis, are associated with premature births, and can cause gonorrhea or blood poisoning.
Further expanding the bacterial database
First author Wei Chen, PhD student at the Department of Bioscience at the TUM School of Natural Sciences in Garching, emphasizes: "Our innovative approach is not to look directly for the pathogenic bacteria, but only for their metabolic products. This allows us to detect them indirectly, but much more quickly."
Prof. Nicole Strittmatter also sees great opportunities for use in personalized medicine, in which the therapy is precisely tailored to the respective patient: "This is one of the most important future topics in biotechnology and medicine. Targeted interventions can dramatically improve the chances of successful treatment. As analysts, we develop modern tools and methods for doctors to do this."
The biomarker database now needs to be further expanded to enable the regular use of the new method in clinical practice. According to the researchers, a total of over 1400 bacterial pathogens are known and described. Their specific metabolic products should now be identified and included.
Original publication
Wei Chen, Min Qiu, Petra Paizs, Miriam Sadowski, Toma Ramonaite, Lieby Zborovsky, Raquel Mejias-Luque, Klaus-Peter Janßen, James Kinross, Robert D. Goldin, Monica Rebec, Manuel Liebeke, Zoltan Takats, James S. McKenzie, Nicole Strittmatter; "Universal, untargeted detection of bacteria in tissues using metabolomics workflows"; Nature Communications, Volume 16, 2025-1-2
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Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.
Topic world Diagnostics
Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.
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Mass spectrometry enables us to detect and identify molecules and reveal their structure. Whether in chemistry, biochemistry or forensics - mass spectrometry opens up unexpected insights into the composition of our world. Immerse yourself in the fascinating world of mass spectrometry!
Topic World Mass Spectrometry
Mass spectrometry enables us to detect and identify molecules and reveal their structure. Whether in chemistry, biochemistry or forensics - mass spectrometry opens up unexpected insights into the composition of our world. Immerse yourself in the fascinating world of mass spectrometry!