Brodmann area 25 (BA25) is an area in the cerebral cortex of the brain and delineated based on its cytoarchitectonic characteristics.
It is also called the subgenual area or area subgenualis.
It is the 25th "Brodmann area" defined by Korbinian Brodmann (thus its name).
BA25 is located in the cingulate region as a narrow band in the caudal portion of the subcallosal area adjacent to the paraterminal gyrus. The posterior parolfactory sulcus separates the paraterminal gyrus from BA25. Rostrally it is bound by the prefrontal area 11 of Brodmann. 
Brodman described this area as it is labeled now in 1909. Originally in 1905, Brodman labeled the area as part of area 24. In 1909, he divided the area into area 24 and 25.
One study has noted that BA25 is metabolically overactive in treatment-resistant depression and has found that chronic deep brain stimulation in the white matter adjacent to the area is a successful treatment for some patients.
Notes and References
- ^ subgenual area 25. braininfo.rprc.washington.edu, retrieved November 18, 2006.
- ^ area 25 of Brodmann-1909. braininfo.rprc.washington.edu, retrieved November 19, 2006.
- ^ Deep Brain Stimulation for Treatment-Resistant Depression neuron.org, March 3, 2005. Retrieved November 18, 2006.
|Brain: telencephalon (cerebrum, cerebral cortex, cerebral hemispheres)|
|Primary sulci/fissures||Medial longitudinal, Lateral, Central, Parietoöccipital, Calcarine, Cingulate, Callosal Collateral fissure|
|Frontal lobe||Precentral gyrus (Primary motor cortex, 4), Precentral sulcus, Superior frontal gyrus/Frontal eye fields (6, 8, 9), Middle frontal gyrus (46), Inferior frontal gyrus (44-Pars opercularis, 45-Pars triangularis), Orbitofrontal cortex (10, 11, 12, 47)|
|Parietal lobe||Somatosensory cortex (Primary (1, 2, 3, 43), Secondary (5)), Precuneus (7m), Parietal lobules (Arcuate fasciculus/Superior (7l), Inferior (40)), Angular gyrus (39), Intraparietal sulcus, Marginal sulcus|
|Occipital lobe||Primary visual cortex (17), Cuneus, Lingual gyrus, 18, 19 - Lateral occipital sulcus|
|Temporal lobe||Primary auditory cortex (41, 42), Superior temporal gyrus (38, 22), Middle temporal gyrus (21), Inferior temporal gyrus (20), Fusiform gyrus (37) Medial temporal lobe (Amygdala, Hippocampus, Parahippocampal gyrus (27, 28, 34, 35, 36)|
|Cingulate cortex/gyrus||Subgenual area (25), anterior cingulate (24, 32, 33), Posterior cingulate (23, 31), Retrosplenial cortex (26, 29, 30), Supracallosal gyrus|
|white matter tracts||Corpus callosum (Splenium, Genu, Rostrum, Tapetum), Septum pellucidum, Internal capsule, Corona radiata, External capsule, Olfactory tract, Fornix (Commissure of fornix), Anterior commissure, Posterior commissure Terminal stria Superior and Inferior longitudinal fasciculus, uncinate fasciculus, cingulum, Inferior occipitofrontal fasciculus|
|Basal ganglia||Striatum (Putamen,Caudate nucleus, Nucleus accumbens), Globus pallidus, Claustrum, Subthalamic nucleus, Substantia nigra|
|Other||Insular cortex Olfactory bulb, Anterior olfactory nucleus Septal nuclei Basal optic nucleus of Meynert|
|Some categorizations are approximations, and some Brodmann areas span gyri.|