Morphochem announces determination of the X-ray structure of Endothelin Converting Enzyme (ECE-1) complexed with Phosphoramidon
Morphochem AG has announced that they have successfully achieved an important milestone in their research collaboration with Solvay Pharmaceuticals using Morphochem's structural biology tools to support their Endothelin-Converting Enzyme inhibitor program.
Morphochem applied its protein expression, purification, crystallization and structure determination capabilities to generate biostructural information for further optimization of inhibitor compounds against Endothelin-Converting Enzyme.
Commenting on the collaboration, Glenn E. Dale, Head of Biological Sciences at Morphochem said: "We are delighted that Morphochem could rapidly and successfully determine the three-dimensional structure of ECE-1 complexed with phosphoramidon, thereby providing the necessary tools to Solvay for this very important target."
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