Next generation allergy vaccines to be developed in Finland to create effective and safe desensitation therapies

14-Oct-2011 - Finland

VTT Ventures Oy has established a spin-off which develops next generation allergy vaccines. The spin-off is called Desentum Oy, and its operations are based on a VTT patented technology. Years of research, testing and official approval cycles are still required before the vaccines are ready for launch.

VTT holds patents on gene technology which can be applied to alter the structure of an allergen, i.e. a protein causing allergy, so that it will cause less allergic symptoms than the original allergen, while remaining effective in desensitisation therapy.

"The vaccine helps to improve the protection to the allergen, thus, alleviating the symptoms. That’s why we prefer to use the term vaccine, instead of medication," VTT’s Senior Advisor Hans Söderlund explains. The research objective is to develop an orally administered vaccine.

The foundation for this development rests on a scientific breakthrough dating back five years to a co-operation project involving VTT, the University of Eastern Finland and HUCH Skin and Allergy Hospital. Researchers were able to determine how an IgE antibody binds an allergen and were the first to present a detailed 3D structure of this complex. This proved to be different from what scientists around the world had anticipated.

Initially, Desentum Oy will develop a product line of 20 to 25 new hypoallergens which could be used as vaccines for some of the most important allergies. These include pollens (birch, hay, common wormwood, etc.), allergens from pets, and proteins associated with food allergies (fish, nuts, apple, celery). Clinical testing of the first products is anticipated to start within the next three years.

https://www.bionity.com/en/news/134821/next-generation-allergy-vaccines-to-be-developed-in-finland-to-create-effective-and-safe-desensitation-therapies.html