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Gonadoblastoma



Gonadoblastoma
Classification & external resources
ICD-O: M9073/1
MeSH D018238

A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells.

Additional recommended knowledge

Associations

Gonadoblastoma is most often associated with abnormal chromosomal karyotype, gonadal dysgenesis, and the presence of a Y chromosome.

It has been found in association with Turner's syndrome.[1][2]

Classification

Main article: Germ cell tumor

Gonadoblastoma is classified as a germ cell tumor.[citation needed]

Formerly, gonadoblastoma was sometimes regarded as a subset of dysgerminoma. In modern literature, it is sometimes considered to progress to dysgerminoma.[3]

References

  1. ^ Maggio MC, Liotta A, De Grazia E, Cimador M, Di Pace R, Corsello G (2007). "Polycystic ovary and gonadoblastoma in Turner's syndrome". Minerva Pediatr. 59 (4): 397–401. PMID 17947845.
  2. ^ Bianco B, Lipay MV, Melaragno MI, Guedes AD, Verreschi IT (2006). "Detection of hidden Y mosaicism in Turner's syndrome: importance in the prevention of gonadoblastoma". J. Pediatr. Endocrinol. Metab. 19 (9): 1113–7. PMID 17128558.
  3. ^ Cooper C, Cooper M, Carter J, Russell P (2007). "Gonadoblastoma progressing to dysgerminoma in a 55-year-old woman with normal karyotype". Pathology 39 (2): 284–5. doi:10.1080/00313020701230708. PMID 17454768.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Gonadoblastoma". A list of authors is available in Wikipedia.
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