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Additional recommended knowledge
Its main function is to nurture the developing sperm cells through the stages of spermatogenesis. Because of this, it has also been called the "mother cell." It provides both secretory and structural support.
Sertoli cells secrete the following substances:
The junctions of Sertoli cells form the blood-testis barrier, a structure that partitions the interstitial blood compartment of the testis from the adluminal compartment of the seminiferous tubules. Sertoli cells control the entry and exit of nutrients, hormones and other chemicals into the tubules of the testis as well as make the adluminal compartment an immune-privileged site.
The cell is also responsible for establishing and maintaining the spermatogonial stem cell niche, which ensures the renewal of stem cells and the differentiation of spermatogonia into mature germ cells that progress stepwise through the long process of spermatogenesis, ending in the release of spermatozoa. Sertoli cells bind to spermatogonial cells via N-cadherins and galctosyltransferase (via carbohydrate residues).
During the Maturation phase of spermiogenesis, the Sertoli cells consume the unneeded portions of the spermatozoa.
Production of Sertoli cells
Once fully differentiated, the Sertoli cell is unable to proliferate. Therefore, once spermatogenesis has begun, no more Sertoli cells are created.
Recently however, some scientists have found a way to grow these cells outside of the body. This gives rise to the possibility of repairing some defects that cause male infertility.
Sertoli cells are called so because of their eponym Enrico Sertoli, an Italian physiologist who discovered them while studying medicine in the University of Pavia, Italy. 
He published a description of this cell in 1865. The cell was discovered by Sertoli with a Belthle microscope purchased in 1862, which he used while studying medicine.
In the 1865 publication, his first description used the terms "tree-like cell" or "stringy cell" and most importantly he referred to these "mother cells." It was other scientists who used Enrico's family name, Sertoli, to label these cell in publications, starting in 1888. As of 2006, two textbooks that are devoted specifically to the Sertoli cell have been published.
Sertoli-Leydig cell tumour are part of the sex cord-stromal tumour group of ovarian neoplasms.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Sertoli_cell". A list of authors is available in Wikipedia.|