Activin is a related peptide that counteracts inhibin.
Quantification of inhibin A is part of the prenatal quad screen that can be administered during pregnancy at a gestational age of 16-18 weeks. An elevated inhibin A (along with an increased beta-hCG, decreased AFP, and a decreased estriol) is suggestive of the presence of a fetus with Down's syndrome. As a screening test, abnormal quad screen test results need to be followed up with more definitive tests.
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^ Skinner M, McLachlan R, Bremner W (1989). "Stimulation of Sertoli cell inhibin secretion by the testicular paracrine factor PModS". Mol Cell Endocrinol66 (2): 239-49. PMID 2515083.
Aitken D, Wallace E, Crossley J, Swanston I, van Pareren Y, van Maarle M, Groome N, Macri J, Connor J (1996). "Dimeric inhibin A as a marker for Down's syndrome in early pregnancy". N Engl J Med334 (19): 1231-6. PMID 8606718.
^ Robertson D, Pruysers E, Jobling T. "Inhibin as a diagnostic marker for ovarian cancer". Cancer Lett. PMID 17320281.
^ Robertson D, Pruysers E, Burger H, Jobling T, McNeilage J, Healy D (2004). "Inhibins and ovarian cancer". Mol Cell Endocrinol225 (1-2): 65-71. PMID 15451569.