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Activin receptor type 1C
Other names: ACTR-IC, Activin receptor-like kinase 7, ALK-7
Genetic data
Gene code: HUGO code:ACVR1C
Protein Structure/Function
Protein type: Serine/Threonine receptor kinase
Domains: GS domain, TS domain, S/T domain
Taxa expressing:Homo sapiens; homologs: many metazoan phyla
Cell types:ubiquitous
Subcellular localization:Plasma membrane
Enzymatic Data
Catalytic activity:ATP + (receptor-protein) = ADP + (receptor-protein) phosphate
Cofactor(s):Magnesium or manganese

ACVR1C or ALK-7 transduces signals of Nodal. Nodal binds to ACVR2B and then forms a comlex with ACR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.[1]

Symbol ACVR1C
Entrez 130399
HUGO 18123
OMIM 608981
RefSeq NM_145259
UniProt Q8NER5
Other data
Locus Chr. 2 q24.2


  1. ^ Inman, GJ; Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. (Jul 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol Pharmacol. 62 (1). Entrez PubMed 12065756. Retrieved on 2006-07-05.
  This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ACVR1C". A list of authors is available in Wikipedia.
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