Quantitative System Metabolism (QSM)

The QSM™ platform by Doppelganger introduces, for the first time, precise quantification of cellular respiration, ATP production, and substrate utilization—at spatial resolution down to the single-cell level.

This groundbreaking technology empowers researchers, translational scientists, and drug developers to analyze cellular metabolism with unprecedented functional and spatial accuracy. QSM™ provides a robust foundation for data-driven decisions, accelerating research outcomes and advancing the development of novel therapies.

Unique Value for Your Research

• Functional Depth: Quantify key bioenergetic parameters—including oxygen consumption, ATP synthesis, and substrate uptake—directly within the histological tissue context.
• Spatial Precision: Investigate metabolic processes at single-cell resolution and uncover metabolic heterogeneity within complex tissue architectures.
• Clinical Relevance: Work with fresh, frozen, or FFPE tissue to enable both prospective studies and retrospective cohort analyses.

With QSM™, researchers can uncover new mechanisms of action, strengthen the biological significance of findings, and validate potential therapeutic targets with greater confidence. The platform not only supports biomarker identification and validation but also generates robust, publication-ready data that streamline translation from preclinical discovery to clinical application.

QSM™ defines a new generation of metabolic analysis: functionally powerful, spatially precise, and readily applicable across basic research and pharmaceutical development.