EMBO Gold Medal 2011 awarded to Simon Boulton
Groundbreaking research on DNA repair, genome integrity and cancer
- Discovering the gene RTEL1 as an anti-recombinase that impacts on genome stability and cancer and counteracts toxic recombination, which is also required in meiosis to execute non-crossover repair.
- Discovering the PBZ motif and establishing that ALC1 (Amplified in Liver Cancer 1) is a poly(ADP-ribose)-activated chromatin-remodelling enzyme required for DNA repair. Poly (ADP-ribosyl)ation (PAR) is a post-translational modification of proteins that play an important role in mediating protein interactions and the recruitment of specific protein targets. These results provided new insights into the mechanisms by which PAR regulates DNA repair.
- Discovering that the Fanconi Anemia proteins FANCM and FAAP24 are required for checkpoint-kinase signalling (ATR) in response to DNA damage and establishing that DNA repair defects of Fanconi Anemia cells can be suppressed by blocking error prone repair by non-homologous end joining.
These discoveries gave rise to novel therapeutic approaches. Boulton’s laboratory demonstrated that cells that over-express the ALC1 enzyme are highly susceptible to eradication by the chemotherapeutic Bleomycin. Since ALC1 is amplified in over 50 percent of human liver cancers, these findings may have important implications for liver cancer treatment.
The prizewinner also showed that DNA repair defects of Fanconi Anemia cells can be suppressed by blocking non-homologous end joining (NHEJ). This observation raises the possibility that NHEJ inhibitors could be used to suppress cancer predisposition in Fanconi Anemia patients.
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