First human antibodies to reach Alzheimer's target

Roche and MorphoSys announce major milestone in research collaboration

02-Jul-2002

Roche and MorphoSys AG today announced the achievement of an important milestone in their collaboration through MorphoSys' delivery of several antibodies that reach a specific Alzheimer target predefined by Roche.Roche will now further characterize the antibodies in preclinical studies and if suitable examine the most promising antibody in clinical trials. This achievement triggered an undisclosed milestone payment to MorphoSys.

Roche and MorphoSys initiated the collaboration to develop human antibodies targeting a Roche Alzheimer's disease target in September 2000. MorphoSys used its proprietary HuCAL® (Human Combinatorial Antibody Library) library to generate several antibodies against the Roche target, achieving the first two milestones in December 2000 and March 2001. In achieving these two milestones MorphoSys delivered a series of HuCAL® antibodies which were shown to bind selectively to the Roche target in human Alzheimer brain tissue sections. For the most recent milestone MorphoSys generated HuCAL® antibodies demonstrating high affinity binding to the Roche target in both in vitro assays and in an Alzheimer's animal model. MorphoSys will receive development related milestone payments and royalties on any marketed products emerging from the collaboration.

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Topic world Antibodies

Antibodies are specialized molecules of our immune system that can specifically recognize and neutralize pathogens or foreign substances. Antibody research in biotech and pharma has recognized this natural defense potential and is working intensively to make it therapeutically useful. From monoclonal antibodies used against cancer or autoimmune diseases to antibody-drug conjugates that specifically transport drugs to disease cells - the possibilities are enormous

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Topic world Antibodies

Topic world Antibodies

Antibodies are specialized molecules of our immune system that can specifically recognize and neutralize pathogens or foreign substances. Antibody research in biotech and pharma has recognized this natural defense potential and is working intensively to make it therapeutically useful. From monoclonal antibodies used against cancer or autoimmune diseases to antibody-drug conjugates that specifically transport drugs to disease cells - the possibilities are enormous