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Suramin



Suramin
Systematic (IUPAC) name
8-[(4-methyl-3-{[3-({[3-({2-methyl-5-

[(4,6,8-trisulfo-1-naphthyl)carbamoyl] phenyl}carbamoyl)phenyl]carbamoyl}amino) benzoyl]amino}benzoyl)amino]naphthalene- 1,3,5-trisulfonic acid

Identifiers
CAS number 145-63-1
ATC code P01CX02
PubChem 5361
Chemical data
Formula C51H40N6O23S6 
Mol. mass 1297.29
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Suramin is a medicinal drug developed by Oskar Dressel and Richard Kothe of Bayer, Germany in 1916. It is used for treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms. It is under investigation as treatment for prostate cancer.

Additional recommended knowledge

Contents

Chemistry

The molecular formula of suramin is C51H34N6O23S6. It is a symmetric molecule in the center of which lies urea, NH-CO-NH. Suramin contains 8 benzene rings, 4 of which are fused in paires (naphthalene), 4 amide groups in addition to the one of urea and six sulfonate groups. When given as drug it usually contains six sodium ions that form a salt with the six sulfonate groups.

Dosing

Suramin is admistered by a single weekly intravenous injection for six weeks. The dose per injection is 1 g.

Adverse reactions

The most frequent adverse reactions are nausea and vomiting. About 90% of patients will get an urticarial rash (like a nettle or poison ivy-type rash) that disappears in a few days without needing to stop treatment. There is a greater than 50% chance of adrenal cortical damage, but only a smaller proportion will require lifelong corticosteroid replacement. It is common for patients to get a tingling or crawling sensation of the skin with suramin. Suramin will cause clouding of the urine which is harmless: patients should be warned of this to avoid them becoming alarmed.

Kidney damage and exfoliative dermatitis occur less commonly.

Research

Suramin is also used in research as a broad-spectrum antagonist of P2 receptors (ATP receptors) and agonist of Ryanodine receptors.

Manufacturing and availability

Suramin is manufactured by Bayer in Germany as Germanin®. Each vial contains 1g of suramin powder to be reconstituted for injection.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Suramin". A list of authors is available in Wikipedia.
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