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B-cell prolymphocytic leukemia



B-cell prolymphocytic leukemia
Classification & external resources
ICD-O: 9833

B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of chronic lymphocytic leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.

Additional recommended knowledge

It can involve deletions from chromosome 11 and chromosome 13.[1]

It has a relatively poor prognosis.[2]

References

  1. ^ Lens D, Matutes E, Catovsky D, Coignet LJ (2000). "Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)". Leukemia 14 (3): 427-30. PMID 10720137.
  2. ^ Del Giudice I, Davis Z, Matutes E, et al (2006). "IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)". Leukemia 20 (7): 1231-7. doi:10.1038/sj.leu.2404238. PMID 16642047.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "B-cell_prolymphocytic_leukemia". A list of authors is available in Wikipedia.
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