Apax Partners Forms Aerovance, Inc., Through Spin Out of Bayer Biotechnology Respiratory Projects

New Company Raises $32 Million in Series B Financing Led by Apax Partners

23-Aug-2004

Funds advised by Apax Partners today announced the Formation of Aerovance, Inc., a new, independent company dedicated exclusively to developing and commercializing biologic products for respiratory diseases. Aerovance has raised $32 million through a Series B financing led by Apax Partners. Additional investors include Lehman Brothers, NGN Capital and Burrill & Co.

The agreement marries Bayer technology and expertise with the entrepreneurial spirit inherent in a biotech spin out. Under the terms of the agreement, in exchange for a minority equity stake in Aerovance, Bayer Pharmaceuticals Corporation has spun out the rights to two lead products to Aerovance: an IL4/13 receptor antagonist (AER-001) for severe asthma entering Phase II studies and Bikunin (AER-002), a recombinant therapeutic protein for cystic fibrosis and chronic obstructive pulmonary disease (COPD) on track for the filing of an investigational new drug (IND) application. Bayer also spun out additional research-stage and preclinical programs in respiratory disease to Aerovance.

Wolf-Dieter Busse, Ph.D., formerly Senior Vice President of Biotechnology, Bayer Pharmaceuticals, will serve as Chief Executive Officer of Aerovance, leading an experienced team of former Bayer Pharmaceuticals Biotechnology scientific and business professionals. The new company will be based in Berkeley, Calif.

"Over the next 18 months, Aerovance will focus on demonstrating proof of concept for our two lead product candidates which target novel, validated pathways in the respiratory system," said Dr. Busse. "Our strong portfolio will be advanced by a seasoned management team of leading experts in respiratory drug development and protein manufacturing."

"This innovative agreement with Apax Partners supports the continued development of some promising respiratory compounds identified in our former biotechnology research unit, while enabling Bayer Pharmaceuticals to continue to focus on our core therapeutic areas," said Dr. Wolfgang Plischke, President and General Manager, Bayer Pharmaceuticals. "We are pleased that Aerovance will continue to develop these promising compounds."

"The success of novel respiratory therapeutics launched in recent years underscores the unmet medical need for safer and more effective products," said Dr. Lori Rafield, Partner, who heads Apax Partners' U.S. Healthcare investment team. "The formation of Aerovance is a great example of Apax Partners' ability to create solutions that provide strategic alternatives to the healthcare industry and identify attractive new opportunities in drug development."

Founding Board Members board of Aerovance will include Drs. Busse and Rafield as well as Drs. Eliot Charles, also of Apax Partners, and Hingge Hsu of Lehman Brothers. The company will seek three additional Board Members from other healthcare and biotechnology organizations to fill the remaining seats. In addition to Dr. Busse, the management team will include Robert Kuhn, Ph.D., Senior Vice President and Chief Technical Officer, and Rick Fuller, M.D., Senior Vice President and Chief Medical Officer.

The Centers for Disease Control and Prevention estimates that roughly 16 million people in the United States suffer from some form of asthma. The U.S. market for asthma therapies is estimated at $9 billion, with severe asthma accounting for $2 billion - $4 billion in the United States. Cystic fibrosis (CF) is a life-threatening, inherited disease that affects around 70,000 people worldwide. The average life expectancy of a CF patient is 31 years. The current market for all CF therapies is approximately $800 million.

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