Biodistribution of gold nanoparticles designed for renal clearance
The tracking of the radiolabeled Au@DTDTPA nanoparticles by planar scintigraphy and single photon emission computed tomography (SPECT) after intravenous injection associated to the post-mortem analysis showed that these particles exhibit safe behavior: the nanoparticles are removed from the body essentially by renal clearance while no accumulation is observed in the organs (except those involved in the renal clearance (kidneys, bladder)). Moreover the physicochemical properties of Au@DTDTPA-X nanoparticles impede any reticuloendothelial system uptake as reflected by the low uptake by phagocyte-rich organs (liver and spleen). The follow-up by at least three different imaging modalities (X-ray imaging, MRI, scintigraphy), the absence of undesirable accumulation and the removal by urine render Au@DTDTPA nanoparticles very promising for in vivo applications, especially for image-guided radiotherapy.
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