Applied Biosystems and Myriad Proteomics Announce Research Collaboration to Develop Technologies and Applications for Proteomics

15-Aug-2002

FOSTER CITY, CA and Salt Lake City, UT – August 13, 2002 – Applied Biosystems, an Applera Corporation business, and Myriad proteomics Inc., a privately held company founded by Hitachi, Ltd., Friedli Corporate Finance, Oracle Corporation and Myriad Genetics, Inc., today announced a collaboration to develop new technologies and applications for proteomics. Myriad Proteomics intends to use the Applied Biosystems 4700 Proteomics Analyzer with TOF/TOF™ optics as a major platform in its efforts to map the human proteome and to identify drug targets for the prevention and treatment of human disease. Financial terms of the agreement were not disclosed. The collaboration will focus on the development of more effective ways to analyze proteins and pathways that comprise complex biological systems, using mass spectrometry, protein chemistry and bioinformatics. The effort will combine Applied Biosystems' expertise in mass spectrometry and advanced proteomics technologies with Myriad Proteomics’ extensive expertise and technology in protein-protein interactions and protein complex analysis.

“We believe that this collaboration may lead to new and more productive workflows using the Applied Biosystems 4700 Proteomics Analyzer in discovery proteomics including potentially enhanced approaches in protein-protein interaction studies,” said Stephen A. Martin, Ph.D., Director of the Proteomics Research Center at Applied Biosystems. “In addition, we expect to gain insight into advanced applications utilizing the 4700 analyzer for proteomics.”

“We are excited about the combination of capabilities afforded by the Applied Biosystems 4700 Proteomics Analyzer. It will enable us to develop workflows which more efficiently analyze the multiprotein complexes we isolate, which effectively allows us to identify novel protein interactions on a systems scale,” said Sudhir Sahasrabudhe, Ph.D., Chief Scientific Officer of Myriad Proteomics. “Additionally, the collaboration with Applied Biosystems should accelerate the implementation of processes leading to Myriad Proteomics’ identification of novel drug targets.”

Scientists from both Applied Biosystems’ Proteomics Research Center (PRC) in Framingham, MA and Myriad Proteomics’ new laboratory and office site in Salt Lake City are expected to collaborate on the project. The PRC is leveraging Applied Biosystems existing proteomics expertise and internal research capabilities while facilitating collaboration with complementary research and technology partners. The goal is to achieve advances in the production of high quality information by means of significant improvements in throughput, automation, sensitivity and cost efficiency.

The Applied Biosystems 4700 Proteomics Analyzer, introduced in January 2002, is the first commercial instrument to employ the new, high-speed Matrix Assisted Laser Desorption Ionization (MALDI) source and Applied Biosystems TOF/TOF™ Optics, creating advanced Tandem Time of Flight mass spectrometry technology. This technology combination permits fast, accurate identification and characterization of protein samples at throughput rates of as much as 1000 samples per hour - up to ten times faster than current technology. This system could be useful in making the drug development process more efficient and cost effective.

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