My watch list  


Systematic (IUPAC) name
CAS number 50-91-9
ATC code  ?
PubChem 5790
DrugBank APRD00692
Chemical data
Formula C9H11FN2O5 
Mol. mass 246.193 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Floxuridine is an oncology drug that belongs to the class known as antimetabolites. The drug is most often used in the treatment of colorectal cancer.



Floxuridine, an analog of 5-fluorouracil, is a fluorinated pyrimidine.

Meachanism of action

Floxuridine works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil.


Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. The drug was initially marketed by Roche, which also did a lot of the initial work on 5-fluorouracil. The National Cancer Institute was an early developer of the drug. Roche sold its FUDR product line in 2001 to Faulding, which became Mayne Pharma.


In the US the drug is supplied by Mayne Pharma as well as APP and Bedford.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Floxuridine". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE