Cannabinoids are used in patients with cachexia, cytotoxic nausea & vomiting or are unresponsive to other agents.
Cannabis (Marijuana). Most patients prefer smoked or vaporized cannabis over pharmaceutical versions because they do not contain all 66 cannabinoids that are in cannabis, many of which have medicinal applications. CBD is a main cannabinoid not in Marinol or Cesamet.
Midazolam given at the onset of anaesthesia has been shown in recent trials to be as effective as ondansetron, a 5HT3 antagonist in the prevention of post-operative nausea and vomiting. Further studies need to be undertaken.
Lorazepam said to be very good as an adjunct treatment for nausea along with first line medications such as Compazine or Zofran.
Non-pharmaceutical therapies with some evidence of efficacy include acupuncture and hypnosis. All drugs have potential side effects. It is important to try to reduce the baseline risk of nausea and vomiting, particularly with respect to surgery.