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Histamine receptor



The histamine receptors are a class of G-protein coupled receptors with histamine as their endogenous ligand.[1]

Additional recommended knowledge

There are four known histamine receptors:

Comparison

Histamine receptors
Receptor Mechanism Function Antagonists
H1 Gq
H2 Gs
Ca2+
  • speed up sinus rhythm
  • Stimulation of gastric acid secretion
  • Smooth muscle relaxation
  • Inhibit antibody synthesis, T-cell proliferation and cytokine production
H3 Gi
H4 Gi

There are several splice variants of H3 present in various species. Though all of the receptors are 7-transmembrane g protein coupled receptors, H1 and H2 are quite different from H3 and H4 in their activities. H1 causes an increase in phosphoinositol hydrolysis, H2 stimulates gastric acid secretion, and H3 mediates feedback inhibition of histamine.

References

  1. ^ Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL (1997). "International Union of Pharmacology. XIII. Classification of histamine receptors". Pharmacol. Rev. 49 (3): 253–78. PMID 9311023.
  2. ^ Hofstra CL, Desai PJ, Thurmond RL, Fung-Leung WP (2003). "Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells". J. Pharmacol. Exp. Ther. 305 (3): 1212–21. doi:10.1124/jpet.102.046581. PMID 12626656.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Histamine_receptor". A list of authors is available in Wikipedia.
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