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Angiotensin receptor



angiotensin II receptor, type 1
Identifiers
Symbol AGTR1
Alt. Symbols AGTR1B
Entrez 185
HUGO 336
OMIM 106165
RefSeq NM_000685
UniProt P30556
Other data
Locus Chr. 3 q21-q25
angiotensin II receptor, type 2
Identifiers
Symbol AGTR2
Entrez 186
HUGO 338
OMIM 300034
RefSeq NM_000686
UniProt P50052
Other data
Locus Chr. X q22-q23

The angiotensin receptors are a class of G protein-coupled receptors with angiotensins as ligands.[1] They are important in the renin-angiotensin system: they are responsible for the signal transduction of the main effector hormone.[2]

Additional recommended knowledge

Contents

Structure

The AT1 and AT2 receptors share a sequence identity of ~30%, but have a similar affinity for angiotensin II, which is their main ligand.

Members

Overview table

Receptor Mechanism [3]
AT1
  • Gq/11
  • Gi/o
AT2
  • Gi2 / 3
AT3
AT4

AT1

Main article: Angiotensin II receptor type 1

The AT1 receptor is the best elucidated angiotensin receptor.

Mechanism

It is activated by angiotensin II. It is coupled to Gq/11 and Gi/o and thus activates phospholipase C and increases the cytosolic Ca2+ level, which itself performs cellular mechanisms, as well as activating protein kinase C It also inhibits adenylate cyclase and activate various tyrosine kinases.[2]

Effects

Effects mediated by the AT1 receptor include vasoconstriction, aldosterone synthesis and secretion, increased vasopressin secretion, cardiac hypertrophy, augmentation of peripheral noradrenergic activity, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.[4]

AT2

AT2 receptors are more plentiful in the fetus and neonate. Effects mediated by the AT2 receptor include inhibition of cell growth, fetal tissue development, modulation of extracellular matrix, neuronal regeneration, apoptosis, cellular differentiation and maybe vasodilation.

AT3 and AT4

Other poorly characterized subtypes include the AT3 and AT4 receptors. The AT4 receptor is activated by the angiotensin II metabolite angiotensin IV, and may play a role in regulation of the CNS extracellular matrix.

See also

References

  1. ^ de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T (2000). "International union of pharmacology. XXIII. The angiotensin II receptors". Pharmacol. Rev. 52 (3): 415–72. PMID 10977869.
  2. ^ a b Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). "Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology". Clin. Sci. 112 (8): 417–28. doi:10.1042/CS20060342. PMID 17346243.
  3. ^ Unless else specified in box, then ref is: Senselab
  4. ^ Catt KJ, Mendelsohn FA, Millan MA, Aguilera G (1984). "The role of angiotensin II receptors in vascular regulation". J. Cardiovasc. Pharmacol. 6 Suppl 4: S575–86. PMID 6083400.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Angiotensin_receptor". A list of authors is available in Wikipedia.
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