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Chlorobutanol

Chlorobutanol

IUPAC name	1,1,1-Trichloro-2-methyl-2-propanol
Other names	1,1,1-trichloro-2-methyl-2-propanol, chlorbutol, chloreton, chloretone, chlortran, trichloro-tert-butyl alcohol, 1,1,1-trichloro-tert-butyl alcohol, 2-(trichloromethyl)propan-2-ol, 1,1,1-trichloro-2-methyl-2-propanol, tert-Trichlorobutyl alcohol, trichloro-tert-butanol, trichlorisobutylalcohol, 2,2,2-trichloro-1,1-dimethylethanol
Identifiers
CAS number	57-15-8
Properties
Molecular formula	C₄H₇Cl₃O
Molar mass	175.5 g/mol
Appearance	White solid
Melting point	95 - 99°C
Boiling point	167°C
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Chlorobutanol, or 1,1,1-trichloro-2-methyl-2-propanol, is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate.

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Chemical synthesis

Chlorobutanol is formed by the simple nucleophilic addition of chloroform and acetone. The reaction is base driven by potassium or sodium hydroxide.

v • d • e Antiemetics and antinauseants (A04)
Serotonin (5-HT₃) antagonists	Ondansetron • Granisetron • Tropisetron • Dolasetron • Palonosetron
Other	Scopolamine • Cerium oxalate • Chlorobutanol • Metopimazine • Cannabinoids (Dronabinol, Nabilone) • NK1 receptor antagonist (Aprepitant)