GlaxoSmithKline and Galapagos enter into drug discovery and development alliance in Osteoarthritis
The aim of this turn-key agreement is for Galapagos to expand its portfolio of novel validated targets in the field of osteoarthritis, to conduct compound screening, identify tractable hits, pursue a number of hit-to-lead programmes, and develop the resulting leads into candidate selection compounds through to a successful Proof of Concept in clinical research Phase IIA. GSK will have exclusive options to further develop and commercialise these compounds on a worldwide basis. Galapagos will have the right to further develop and commercialise compounds for which GSK does not exercise its option. Galapagos will contract a substantial part of the activities to its service division, BioFocus.
The focus of the alliance's efforts will be on delivering disease-modifying drugs with clinical Proof of Concept for osteoarthritis to GSK's global research and development organisation. The overall strategy will be to identify genes that stimulate anabolic repair processes (chondrogenesis) and inhibit catabolic (breakdown) activity in affected joints.
Under the terms of the agreement, Galapagos will receive an upfront technology access fee of 4 million from GSK. Upon successful completion of all agreed alliance programme criteria, Galapagos stands to receive up to 65 million in success-based milestones for a successful drug development programme. In addition, Galapagos will receive up to double-digit royalties on commercial sales of alliance products. Further to the agreement, on the realisation of a defined future milestone, GSK will make an equity investment of up to 3 million in Galapagos.
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