25-Oct-2016 - Vanderbilt University

DNA damage response protein

Researchers at Vanderbilt University and Vanderbilt University Medical Center have determined that a previously uncharacterized protein called ETAA1 is a “replication stress response protein” with an essential role in maintaining the integrity of the genome.

The finding by David Cortez , Ph.D., Walter Chazin , Ph.D., and colleagues adds to the list of proteins known to be involved in DNA replication, the accurate copying of the genetic code each time a cell divides.

In particular, ETAA1 acts at stalled replication forks, where the double-helical DNA molecule splits apart and copies are made of each strand. The stalled replication fork has been compared to a paper jam in a copy machine. ETAA1 is one of a number of proteins that can undo the “jam.”

Quantity is important. Too much or too little of the protein is associated with DNA damage. Similarly, mutations in the ETAA1 gene are known to increase the risk for pancreatic cancer.

Facts, background information, dossiers
More about Vanderbilt University
  • News

    New study supports remdesivir as COVID-19 treatment

    The news about remdesivir, the investigational anti-viral drug that has shown early promise in the fight against COVID-19, keeps getting better. This week researchers at Vanderbilt University Medical Center (VUMC), the University of North Carolina at Chapel Hill and Gilead Sciences reported ... more

    € 1 Million Research Grant Awarded for the First Time

    Merck awarded a grant known as the Future Insight Prize for the first time. Pardis Sabeti, Harvard University and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA, and James Crowe, Vanderbilt University Medical Center, Nashville, Tennessee, USA, were recognized for thei ... more

    Evolution of a deadly virus

    Infections caused by the mosquito-borne eastern equine encephalitis virus (EEEV) are severe and have high mortality rates for horses - 90 percent - and humans - 33 percent, with significant brain damage in most human survivors. Florida has been hypothesized to be the source of EEEV epidemic ... more

  • Videos

    Organ-on-a-chip mimics heart’s biomechanical properties

    Video taken through a microscope shows I-Wire heart fiber. left, beating at different frequencies. The black circle, right, is the flexible cantilever that measures the force of the fiber’s contractions. (Veniamin Sidorov / VIIBRE /Vanderbilt) more