Oxford Expression Technologies Signs Two New Research Collaboration Agreements

R&D projects aim to enhance portfolio of baculovirus protein expression systems

27-Nov-2009 - United Kingdom

Oxford Expression Technologies Ltd (OET has signed research collaboration agreements with ParaTechs and LifeSensors. The projects aim to enhance and expand OET’s flashBAC™ portfolio of baculovirus protein expression systems.

OET’s propriety flashBAC technology is a baculovirus based recombinant system enabling the production of multiple recombinant viruses in a one-step process. The system is suitable for small and large scale protein expression and is already enabling scientists to produce proteins faster, more easily and cost-effectively.

The collaboration with ParaTechs will investigate the potential impact of expressing a Vankyrin gene in tandem with a foreign gene on the quality and yield of the foreign protein and to evaluate whether any benefits are enhanced by using the flashBAC system, which is already known to increase recombinant protein yields beyond those achieved using a conventional vector. This project will also compare flashBAC vectors expressing Vankyrin gene-fusions in ParaTechs Vankyrin-Enhanced cell lines, with standard insect cell lines.

Under the agreement with LifeSensors, the two companies will work together to incorporate a SUMO (small ubiquitin-like modifier) tag into the flashBAC system, and evaluate whether this increases the quality of protein produced. The use of SUMO as a fusion tag has been shown to dramatically increase yield and solubility of protein in more traditional systems. The two companies are hoping that SUMO will create an even more powerful flashBAC system.

https://www.bionity.com/en/news/110048/oxford-expression-technologies-signs-two-new-research-collaboration-agreements.html