Bio-Rad Laboratories

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RNA Therapeutics: Ultrasensitive detection and absolute quantification with Droplet Digital PCR

Bio-Rad Laboratories Ltd.

Transforming Bioanalysis of RNA Therapeutics, from Discovery and Development to Manufacturing QC

Advances in therapeutic RNAs have exploded in recent years. These novel drugs have the potential to make personalized medicine a reality and, at the same time, make the term “undruggable” obsolete. Therapeutic RNAs can be used to provide a sequence-specific modulation of gene expression to cause a desired biological response with a beneficial health outcome. Collectively, RNA therapeutics consist of multiple types of RNAs that include small activating RNAs (saRNA), antisense oligonucleotides (ASO), microRNAs (miRNA), small interfering RNAs (siRNA), and messenger RNAs (mRNA). ddPCR technology has proven to be an invaluable analytical asset and is extensively used at various stages of the RNA development and production process to support the development and production of safe and effective RNA-based therapeutics.

White Paper classification

Applications

Biodistribution studies
Biomarker analysis
Biomarker analysis
biomarker discovery
Copy number variant analysis
Copy Number Variation analysis
Copy Number Variation analysis
dPCR
droplet digital PCR
gene expression analysis
Mutation Detection analysis
Mutation Detection analysis
Poly(A) tail level determination
Single-Cell Analysis

Product categories

ddPCR

Target Industries

Biotechnology
Pharma

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RNA Therapeutics: Ultrasensitive detection and absolute quantification with Droplet Digital PCR

Transforming Bioanalysis of RNA Therapeutics, from Discovery and Development to Manufacturing QC

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