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CD44




CD44 molecule (Indian blood group)
PDB rendering based on 1poz.
Available structures: 1poz, 1uuh, 2i83
Identifiers
Symbol(s) CD44; CDW44; CSPG8; ECMR-III; HCELL; IN; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH-I; Pgp1
External IDs OMIM: 107269 MGI: 88338 Homologene: 508
RNA expression pattern

Additional recommended knowledge

More reference expression data

Orthologs
Human Mouse
Entrez 960 12505
Ensembl ENSG00000026508 ENSMUSG00000005087
Uniprot P16070 P15379
Refseq NM_000610 (mRNA)
NP_000601 (protein)
NM_001039150 (mRNA)
NP_001034239 (protein)
Location Chr 11: 35.12 - 35.21 Mb Chr 2: 102.61 - 102.7 Mb
Pubmed search [1] [2]

The CD44 protein is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs).

This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. Gene transcription is at least in part activated by beta catenin and Wnt signalling (also linked to tumour development). The protein is a determinant for the Indian blood group system.

  • CD44, along with CD25, is used to track early T cell development in the thymus.
  • CD44 expression is an indicative marker for effector-memory T-cells. It is tracked with CFSE chemical tagging.

CD44 found on breast and prostate cancer stem cells.[1]

References

  1. ^ Li et al : "Byond tumorigenesis : cancer stem cells in metastasis" Cell Research (2007) 17:3-14 doi:10.1038/sj.cr.7310118

Further reading

  • Günthert U (1994). "CD44: a multitude of isoforms with diverse functions.". Curr. Top. Microbiol. Immunol. 184: 47-63. PMID 7508842.
  • Yasuda M, Nakano K, Yasumoto K, Tanaka Y (2003). "CD44: functional relevance to inflammation and malignancy.". Histol. Histopathol. 17 (3): 945-50. PMID 12168806.
  • Sun CX, Robb VA, Gutmann DH (2003). "Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation.". J. Cell. Sci. 115 (Pt 21): 3991-4000. PMID 12356905.
  • Assimakopoulos D, Kolettas E, Patrikakos G, Evangelou A (2003). "The role of CD44 in the development and prognosis of head and neck squamous cell carcinomas.". Histol. Histopathol. 17 (4): 1269-81. PMID 12371152.
  • Ponta H, Sherman L, Herrlich PA (2003). "CD44: from adhesion molecules to signalling regulators.". Nat. Rev. Mol. Cell Biol. 4 (1): 33-45. doi:10.1038/nrm1004. PMID 12511867.
  • Martin TA, Harrison G, Mansel RE, Jiang WG (2004). "The role of the CD44/ezrin complex in cancer metastasis.". Crit. Rev. Oncol. Hematol. 46 (2): 165-86. PMID 12711360.
  • [3] Articles at IHOP.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD44". A list of authors is available in Wikipedia.
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