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P-selectin




Selectin P (granule membrane protein 140kDa, antigen CD62)
PDB rendering based on 1fsb.
Available structures: 1fsb, 1g1q, 1g1r, 1g1s
Identifiers
Symbol(s) SELP; CD62; CD62P; FLJ45155; GMP140; GRMP; PADGEM; PSEL
External IDs OMIM: 173610 MGI: 98280 Homologene: 2260
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 6403 20344
Ensembl ENSG00000174175 ENSMUSG00000026580
Uniprot P16109 Q32MF1
Refseq NM_003005 (mRNA)
NP_002996 (protein)
XM_982736 (mRNA)
XP_987830 (protein)
Location Chr 1: 167.82 - 167.87 Mb Chr 1: 165.96 - 165.99 Mb
Pubmed search [1] [2]

P-selectin is a cell adhesion molecule (CAM) found in granules in endothelial cells (cells lining blood vessels) and activated platelets. Other names for P-selectin include CD62P, Granule Membrane Protein 140 (GMP-140), and Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM). It was first shown to be found in endothelial cells in 1989.

Additional recommended knowledge

Contents

Function

P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface.

Thrombin is one trigger which can stimulate endothelial-cell release of P-selectin and recent studies suggest an additional Ca2+-independent pathway involved in release of P-selectin. [1]

Ligands for P-selectin on eosinophils and neutrophils are similar sialylated, protease-sensitive, endo-beta-galactosidase-resistant structures, clearly different than those reported for E-selectin, and suggest disparate roles for P-selectin and E-selectin during recruitment during inflammatory responses. [2]

Location

Endothelial cells: stored in the membrane of Weibel-Palade bodies.

Platelets: stored in alpha-granules.

See also

  • Selectin

Further reading

  • Ryan US, Worthington RE (1992). "Cell-cell contact mechanisms.". Curr. Opin. Immunol. 4 (1): 33-7. PMID 1375831.
  • Bajorath J, Stenkamp R, Aruffo A (1994). "Knowledge-based model building of proteins: concepts and examples.". Protein Sci. 2 (11): 1798-810. PMID 7505680.
  • Varki NM, Varki A (2002). "Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans.". Semin. Thromb. Hemost. 28 (1): 53-66. doi:10.1055/s-2002-20564. PMID 11885026.
  • Furie B, Furie BC (2004). "Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation.". Trends in molecular medicine 10 (4): 171-8. doi:10.1016/j.molmed.2004.02.008. PMID 15059608.
  • Cambien B, Wagner DD (2004). "A new role in hemostasis for the adhesion receptor P-selectin.". Trends in molecular medicine 10 (4): 179-86. doi:10.1016/j.molmed.2004.02.007. PMID 15059609.
  • Chen M, Geng JG (2006). "P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis.". Arch. Immunol. Ther. Exp. (Warsz.) 54 (2): 75-84. doi:10.1007/s00005-006-0010-6. PMID 16648968.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "P-selectin". A list of authors is available in Wikipedia.
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