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Angiotensin-converting enzyme




Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
PDB rendering based on 1o86.
Available structures: 1o86, 1o8a, 1uze, 1uzf, 2c6f, 2c6n, 2iul, 2iux, 2oc2
Identifiers
Symbol(s) ACE; ACE1; CD143; DCP; DCP1; MGC26566
External IDs OMIM: 106180 MGI: 87874 Homologene: 37351
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 1636 11421
Ensembl ENSG00000159640 ENSMUSG00000020681
Uniprot P12821 Q3TU20
Refseq NM_000789 (mRNA)
NP_000780 (protein)
NM_009598 (mRNA)
NP_033728 (protein)
Location Chr 17: 58.91 - 58.94 Mb Chr 11: 105.78 - 105.81 Mb
Pubmed search [1] [2]

Angiotensin I converting enzyme (ACE, EC 3.4.15.1) is an exopeptidase.

Additional recommended knowledge

Contents

Functions

It has two primary functions:

  • it is involved in the inactivation of bradykinin, a potent vasodilator.

These two actions of ACE make it an ideal target in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in decreased formation of Angiotensin II (a far more potent vasoconstrictor than Angiotensin I) and decreased inactivation of bradykinin.

Synonyms

ACE is also known as:

Genetics

The ACE gene, ACE, encodes 2 isozymes. The somatic isozyme is expressed in many tissues, including vascular endothelial cells, epithelial kidney cells, and testicular Leydig cells, whereas the germinal is expressed only in sperm.

See also

References

  1. ^ Physiology at MCG 7/7ch09/7ch09p16

Further reading

  • Niu T, Chen X, Xu X (2002). "Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: therapeutic implications.". Drugs 62 (7): 977-93. PMID 11985486.
  • Roĭtberg GE, Tikhonravov AV, Dorosh ZhV (2004). "[Role of angiotensin-converting enzyme gene polymorphism in the development of metabolic syndrome]". Ter. Arkh. 75 (12): 72-7. PMID 14959477.
  • Vynohradova SV (2005). "[The role of angiotensin-converting enzyme gene I/D polymorphism in development of metabolic disorders in patients with cardiovascular pathology]". Tsitol. Genet. 39 (1): 63-70. PMID 16018179.
  • König S, Luger TA, Scholzen TE (2006). "Monitoring neuropeptide-specific proteases: processing of the proopiomelanocortin peptides adrenocorticotropin and alpha-melanocyte-stimulating hormone in the skin.". Exp. Dermatol. 15 (10): 751-61. doi:10.1111/j.1600-0625.2006.00472.x. PMID 16984256.
  • Sabbagh AS, Otrock ZK, Mahfoud ZR, et al. (2007). "Angiotensin-converting enzyme gene polymorphism and allele frequencies in the Lebanese population: prevalence and review of the literature.". Mol. Biol. Rep. 34 (1): 47-52. doi:10.1007/s11033-006-9013-y. PMID 17103020.
  • Castellon R, Hamdi HK (2007). "Demystifying the ACE polymorphism: from genetics to biology.". Curr. Pharm. Des. 13 (12): 1191-8. PMID 17504229.
  • Lazartigues E, Feng Y, Lavoie JL (2007). "The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases.". Curr. Pharm. Des. 13 (12): 1231-45. PMID 17504232.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Angiotensin-converting_enzyme". A list of authors is available in Wikipedia.
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