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Toll-like receptor 1
PDB rendering based on 1fyv.
TLR1; CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; TIL; rsc786
OMIM: 601194 MGI: 1341295
• transmembrane receptor activity • protein binding • triacylated lipoprotein binding
• plasma membrane • integral to plasma membrane • phagocytic vesicle
• inflammatory response • signal transduction • activation of NF-kappaB-inducing kinase • macrophage activation • detection of triacylated bacterial lipoprotein • positive regulation of tumor necrosis factor biosynthetic process • innate immune response • positive regulation of interleukin-6 biosynthetic process
RNA expression pattern
Additional recommended knowledge
More reference expression data
(mRNA) XP_001129777 (protein) NM_030682
(mRNA) NP_109607 (protein)
Chr 4: 38.47 - 38.48 Mb
Chr 5: 65.2 - 65.21 Mb
TLR 1 is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
Entrez Gene: TLR1 toll-like receptor 1. ^ Further reading
Lien E, Ingalls RR (2002). "Toll-like receptors.". Crit. Care Med. 30 (1 Suppl): S1-11. PMID 11782555.
Transmembrane receptors: immune receptors Cytokine receptor Type I: interleukin ( IL-2, IL-3) - CSF (Erythropoietin, GM-CSF, G-CSF) - Glycoprotein 130/Oncostatin M - Leukemia inhibitory factor - common subunits (Common gamma chain, CSF2RB)
interleukin (IL22RA2) - interferon (IFNAR, IFNGR)
Chemokine - TGF-beta - Tumor necrosis factor Pattern recognition/ Toll-like TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 Fc receptor ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal Lymphocyte homing receptor CD44 - L-selectin - VLA-4 - LFA-1 other Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger
This article is licensed under the
GNU Free Documentation License. It uses material from the Wikipedia article "TLR_1". A list of authors is available in Wikipedia.
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