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TLR 1




Toll-like receptor 1
PDB rendering based on 1fyv.
Available structures: 1fyv
Identifiers
Symbol(s) TLR1; CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; TIL; rsc786
External IDs OMIM: 601194 MGI: 1341295 Homologene: 20694
RNA expression pattern

Additional recommended knowledge

More reference expression data

Orthologs
Human Mouse
Entrez 7096 21897
Ensembl ENSG00000174125 ENSMUSG00000044827
Uniprot Q15399 Q6A0E8
Refseq XM_001129777 (mRNA)
XP_001129777 (protein)
NM_030682 (mRNA)
NP_109607 (protein)
Location Chr 4: 38.47 - 38.48 Mb Chr 5: 65.2 - 65.21 Mb
Pubmed search [1] [2]

TLR 1 is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria.


The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.[1]


References

  1. ^ Entrez Gene: TLR1 toll-like receptor 1.

Further reading

  • Lien E, Ingalls RR (2002). "Toll-like receptors.". Crit. Care Med. 30 (1 Suppl): S1-11. PMID 11782555.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "TLR_1". A list of authors is available in Wikipedia.
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