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Modern medicine sees cancer as a disease in which malignant tissue formation occurs. The disruption of the cell cycle and cell death is present in all very different forms. Cancer refers to diseases in which metastasis formation is present or possible. The most important current types of treatment are surgical removal of tissue, radiotherapy, medical treatment and hyperthermic or electrical therapies. New approaches look at viral or vaccination therapies.
Breakpoint Therapeutics is a newly founded company that will discover and develop new anti-cancer drugs. By targeting the DNA damage response (“DDR”) in cancer cells, Breaktpoint Therapeutics aims to advance to clinical development first-in-class oncology drugs that interfere with DNA repair and re more
AC BioScience is a start-up biotech company with an innovative vision and business model. We are dedicated to developing new therapies to fight a range of cancers. Founded by Andreas Schläpfer and Professor Christian Auclair, the company is leading a paradigm shift in cancer therapeutics. AC BioSc more
SurgicEye has shown in its short history growth and excellence in business, application, and product development for improvements in cancer surgery. SurgicEye was founded in 2008 as a spin-off from an interdisciplinary engineering and medical team at Technische Universität München (TUM).SurgicEye es more
The constant battle against infectious pathogens has had a decisive influence on the human immune system over the course of our evolution. A key role in our adaptation to pathogens is played by HLA molecules. These proteins activate the immune system by presenting it with fragments of pathogens that more
RNA, or ribonucleic acid, is present in the cells of all living beings and required to synthesize proteins. A research team at the University of California, Riverside, has discovered the structure of a novel RNA-modifying enzyme, ZCCHC4, and identified the mechanism that controls how this enzyme rec more
Mitochondria burn oxygen and provide energy for the body. Cells lacking oxygen or nutrients have to change their energy supply quickly in order to keep growing. In a study published in Nature, scientists from the Max Planck Institute for Biology of Ageing have now shown that mitochondria are reprogr more
There may be an ideal waiting period for delivering multiple cancer drugsResearchers led by members of the Department of Systems Biology at Harvard Medical School had been studying how silencing MDMX, an oncogene, affected the dynamics of p53, a natural tumor suppressor, in cancer cells when the ... more
First of new generation of cancer drugs granted European approvalA new drug for ovarian cancer, developed by researchers at the University of Cambridge and AstraZeneca, has become the first of new class of drugs, known as PARP-inhibitors, to be granted approval anywhere in the world. The drug, L ... more
ICR Researchers led by Dr Alessandro Vannini have captured images of molecular machinery called RNA Polymerase III in the act of transcribing a gene in exquisite and unprecedented detail. Animation provided by Phospho Biomedical Animation more
A key observation in these presented results was the magnitude of hypermethylation in PC3 cells, which occurred at almost all of the inactive CpG island genes. A second key observation was that when PRC marks were depleted, a PC3 hypermethylation was more
Cell death is important for multicellular homeostasis but it also has an unfortunate role in human diseases more
To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million fe more
Today’s big news has been the story that the World Health Organisation (WHO) has classified processed meat (including bacon, ham, and salami) as a Group 1 carcinogen. This places it in the same group as smoking, which has led to a number of headlines claiming that it means the risk from the two is t more
Ginger is a spice that can be commonly found in supermarkets and in the kitchen, either as the fresh root, or in dried, powdered form. It adds a strong, pungent flavour to dishes as a consequence of a number of chemical compounds it contains; additionally, these compounds are altered when the ginger more
The first of the 2018 Nobel Prizes is awarded. The 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by stimulating the immune system to attack tumour cells. This graphic takes a look at the prize-winning research. more
MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a single guide RNA (sgRNA) and directs DNA cleavage at a prede more
Computer aided detection and classification of Pap smear cell images using principal component analysisPonnusamy Sukumar; Samikannu RaviInternational Journal of Bio-Inspired Computation, Vol. 11, No. 4 (2018) pp. 257 - 266Pap smear is a screening methodology employed in cervix cancer detection and more
Viruses, Vol. 10, Pages 352: HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses Viruses doi: 10.3390/v10070352 Authors: Laura Menotti Elisa Avitabile Valentina Gatta Paolo Malatesta Biljana Petrovic Gabriella Campadelli-Fiume more
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