Cancer

Companies Cancer

News Cancer

• New tool helps to ‘spot the difference’ in genome organisation
  

  The way DNA is organized in the cell nucleus is very important for the normal development and function of the cell. A mutation that affects the packaging of the genetic material in the cell nucleus can lead to developmental disorders or diseases such as cancer. A team of scientists from the Max Plan more

• Merck Awards Grant to Combined Therapeutics for its Nucleic Acid Platform
  

  Merck announced that Combined Therapeutics Inc., Cambridge, Massachusetts, USA, has been selected as the North American winner of its 2020 Advance Biotech Grant Program. The biotechnology company was selected for its innovative nucleic acid platform which, combined with virotherapy, has the potentia more

• Puzzle solved after 16 years
  

  A research group from Würzburg has now been able to clarify the long-standing question of how the protein complex CDK-activating kinase (CAK), which controls the central processes of cell division and transcription, is activated. The group analyzed the active form of the protein/CAK complex and was more

Videos Cancer

Timing Cancer Treatment

There may be an ideal waiting period for delivering multiple cancer drugsResearchers led by members of the Department of Systems Biology at Harvard Medical School had been studying how silencing MDMX, an oncogene, affected the dynamics of p53, a natural tumor suppressor, in cancer cells when the ... more

PARP-inhibitors: A New Generation of Cancer Drugs

First of new generation of cancer drugs granted European approvalA new drug for ovarian cancer, developed by researchers at the University of Cambridge and AstraZeneca, has become the first of new class of drugs, known as PARP-inhibitors, to be granted approval anywhere in the world. The drug, L ... more

ICR Researchers use Cryo-Electron Microscopy to zoom in on DNA code being read in cells

ICR Researchers led by Dr Alessandro Vannini have captured images of molecular machinery called RNA Polymerase III in the act of transcribing a gene in exquisite and unprecedented detail. Animation provided by Phospho Biomedical Animation more

White papers Cancer

• Expression Analysis of ABC Transporters in Lung Cancer Cell Lines Using a RealTime ready qPCR Focus Panel
  

  The novel small molecule inhibitors are often substrates of ABC transporters which influence the pharmacokinetic parameters of the drug candidates and cause drug resistance of tumor cells. Therefore expression profiling of ABC transporter genes in ce more

• Real-Time Analysis of LNCaP Cell Growth in Different Media
  

  Our results suggest that the influence of androgen receptor-stimulating or -blocking substances strongly depends upon the composition of the growth medium. The use of hormone-depleted FBS in combination with phenol red-free medium is strongly recomme more

• Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes
  

  To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million fe more

Infographics Cancer

A Rough Guide to the IARC’s Carcinogen Classifications

Today’s big news has been the story that the World Health Organisation (WHO) has classified processed meat (including bacon, ham, and salami) as a Group 1 carcinogen. This places it in the same group as smoking, which has led to a number of headlines claiming that it means the risk from the two is t more

The Chemistry of Ginger

Ginger is a spice that can be commonly found in supermarkets and in the kitchen, either as the fresh root, or in dried, powdered form. It adds a strong, pungent flavour to dishes as a consequence of a number of chemical compounds it contains; additionally, these compounds are altered when the ginger more

Unleashing our immune systems against cancer

The first of the 2018 Nobel Prizes is awarded. The 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by stimulating the immune system to attack tumour cells. This graphic takes a look at the prize-winning research. more

Publications Cancer

• MicroRNA-focused CRISPR-Cas9 library screen reveals fitness-associated miRNAs [ARTICLE]

  MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a single guide RNA (sgRNA) and directs DNA cleavage at a prede more

• Computer aided detection and classification of Pap smear cell images using principal component analysis

  Computer aided detection and classification of Pap smear cell images using principal component analysisPonnusamy Sukumar; Samikannu RaviInternational Journal of Bio-Inspired Computation, Vol. 11, No. 4 (2018) pp. 257 - 266Pap smear is a screening methodology employed in cervix cancer detection and more

• Viruses, Vol. 10, Pages 352: HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses

  Viruses, Vol. 10, Pages 352: HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses Viruses doi: 10.3390/v10070352 Authors: Laura Menotti Elisa Avitabile Valentina Gatta Paolo Malatesta Biljana Petrovic Gabriella Campadelli-Fiume more