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Modern medicine sees cancer as a disease in which malignant tissue formation occurs. The disruption of the cell cycle and cell death is present in all very different forms. Cancer refers to diseases in which metastasis formation is present or possible. The most important current types of treatment are surgical removal of tissue, radiotherapy, medical treatment and hyperthermic or electrical therapies. New approaches look at viral or vaccination therapies.
CureVac is a leading company in the field of messenger RNA (mRNA) technology with more than 18 years’ expertise in handling and optimizing this versatile molecule for medical purposes. The principle of CureVac's proprietary technology is the use of mRNA as a data carrier to instruct the human body t more
We have been providing our research and routine customers premium antibodies, immunoassays and products for molecular biology since 1982. We take the time to carefully consider all your queries and are pleased to support you in selecting primary antibodies, secondary antibodies and detection system more
A patient that is diagnosed with cancer today will have a genetic screen on their tumor sample to determine their subtype of cancer. Based on the cancer subtype, they are given a first line of treatment. If that doesn't work, they are given a second line of treatment. If that doesn't work, they are more
Researchers at the German Cancer Research Center (DKFZ) studied the immune response to papillomaviruses in mice and discovered a hitherto unknown mechanism by which the pathogens outwit the immune system: At the beginning of the infection cycle, they produce a longer version of a protein that surrou more
Cancer immunotherapies make use of the ability of the immune system to attack cancer cells: they unleash the killer function of T cells, which then attack and eradicate the cancer cells. However, tumors have their own mechanisms to paralyze these attacks. Despite major advances in immunotherapies, t more
AstraZeneca has entered into a new global development and commercialisation agreement with Daiichi Sankyo Company, Limited for DS-1062, Daiichi Sankyo’s proprietary trophoblast cell-surface antigen 2 (TROP2)-directed antibody drug conjugate (ADC) and potential new medicine for the treatment of multi more
There may be an ideal waiting period for delivering multiple cancer drugsResearchers led by members of the Department of Systems Biology at Harvard Medical School had been studying how silencing MDMX, an oncogene, affected the dynamics of p53, a natural tumor suppressor, in cancer cells when the ... more
First of new generation of cancer drugs granted European approvalA new drug for ovarian cancer, developed by researchers at the University of Cambridge and AstraZeneca, has become the first of new class of drugs, known as PARP-inhibitors, to be granted approval anywhere in the world. The drug, L ... more
ICR Researchers led by Dr Alessandro Vannini have captured images of molecular machinery called RNA Polymerase III in the act of transcribing a gene in exquisite and unprecedented detail. Animation provided by Phospho Biomedical Animation more
A key observation in these presented results was the magnitude of hypermethylation in PC3 cells, which occurred at almost all of the inactive CpG island genes. A second key observation was that when PRC marks were depleted, a PC3 hypermethylation was more
Cell death is important for multicellular homeostasis but it also has an unfortunate role in human diseases more
Dysregulation of cellular energy metabolism is a common factor in a variety of disorders including diabetes and obesity as well as cancer more
Today’s big news has been the story that the World Health Organisation (WHO) has classified processed meat (including bacon, ham, and salami) as a Group 1 carcinogen. This places it in the same group as smoking, which has led to a number of headlines claiming that it means the risk from the two is t more
Ginger is a spice that can be commonly found in supermarkets and in the kitchen, either as the fresh root, or in dried, powdered form. It adds a strong, pungent flavour to dishes as a consequence of a number of chemical compounds it contains; additionally, these compounds are altered when the ginger more
The first of the 2018 Nobel Prizes is awarded. The 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by stimulating the immune system to attack tumour cells. This graphic takes a look at the prize-winning research. more
MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a single guide RNA (sgRNA) and directs DNA cleavage at a prede more
Computer aided detection and classification of Pap smear cell images using principal component analysisPonnusamy Sukumar; Samikannu RaviInternational Journal of Bio-Inspired Computation, Vol. 11, No. 4 (2018) pp. 257 - 266Pap smear is a screening methodology employed in cervix cancer detection and more
Viruses, Vol. 10, Pages 352: HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses Viruses doi: 10.3390/v10070352 Authors: Laura Menotti Elisa Avitabile Valentina Gatta Paolo Malatesta Biljana Petrovic Gabriella Campadelli-Fiume more
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