Autophagy

News Autophagy

• Autophagy: the beginning of the end
  

  Autophagy, from the Greek for 'self-eating', is an essential process that isolates and recycles cellular components under conditions of stress or when resources are limited. Cargoes such as misfolded proteins or damaged organelles are captured in a double membrane-bound com-partment called the autop more

• Cleaning craze in the brain
  

  Synapses consist of hundreds of different proteins. For correct transmission of brain signals, their building blocks must constantly be checked for functionality and replaced by new ones. A team of researchers from the Leibniz Institute of Neurobiology Magdeburg, the German Centre for Neurodegenerat more

• Scientists discover novel role for self-recycling process in the brain

  Scientists from the laboratory of Dr. Natalia Kononenko at the CECAD Center of Excellence in Aging Research at the University of Cologne have found out that autophagy – the process of cellular self-recycling, or waste clearance – is dispensable for the survival of the neurons in mice. The new findin more

Videos Autophagy

Nobel lecture: Yoshinori Ohsumi, Nobel Laureate in Physiology or Medicine 2016

Autophagy - an Intracellular Recycling Systemby Yoshinori OhsumiTokyo Institute of Technology, Tokyo, JapanYoshinori Ohsumi delivered his Nobel Lecture on 7 December 2016 at Aula Medica, Karolinska Institutet in Stockholm. more

White papers Autophagy

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to more

Infographics Autophagy

Nobel Prize in Physiology or Medicine 2016

In 2016 the Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi for discovering the mechanisms of autophagy. more

Publications Autophagy

• Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking [Biochemistry]

  Beclin 1 is an essential autophagy protein. Through its coiled-coil domain, Beclin 1 recruits two modulators, Atg14L and UVRAG, to form Atg14L- or UVRAG-containing Beclin 1–Vps34 subcomplexes responsible for Vps34-dependent membrane trafficking processes including autophagy and endosomal trafficking more

• RNA processing for metabolic control

  Metabolism Autophagy is a cellular response to nutrient starvation that allows cells to recycle existing molecules and organelles. Tang et al. investigated the mechanisms by which TORC1 (target of rapamycin complex 1) regulates autophagy. They discovered that regulation occurs through control of RNA more

• Marine Drugs, Vol. 16, Pages 204: Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the ...

  Marine Drugs, Vol. 16, Pages 204: Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hsp90 Marine Drugs doi: 10.3390/md16060204 Authors: Man-Gang Lee Yi-Chang Liu more