Autophagy

News Autophagy

• Scientists discover potential cause of Alzheimer’s Disease
  

  Prevailing theories posit plaques in the brain cause Alzheimer’s disease. New UC Riverside research points to cells’ slowing ability to clean themselves as the likely cause of unhealthy brain buildup.  Along with signs of dementia, doctors make a definitive Alzheimer’s diagnosis if they find a combi more

• A tapeworm drug against COVID-19?
  

  Researchers from the German Center for Infection Research (DZIF) at Charité – Universitätsmedizin Berlin and the University of Bonn have examined the way in which SARS-CoV-2 reprograms the metabolism of the host cell in order to gain an overall advantage. According to their report in Nature Communic more

• Anti-ageing: Spermidine reduces hair loss and protects the heart
  

  As we begin our lives, we get a little older every day. This biological process is irreversible and, with increasing lifespan, is accompanied by a variety of pathological changes that can lead, for example, to heart failure (cardiac insufficiency), the loss of nerve cells (neurodegeneration) or redu more

Videos Autophagy

Nobel lecture: Yoshinori Ohsumi, Nobel Laureate in Physiology or Medicine 2016

Autophagy - an Intracellular Recycling Systemby Yoshinori OhsumiTokyo Institute of Technology, Tokyo, JapanYoshinori Ohsumi delivered his Nobel Lecture on 7 December 2016 at Aula Medica, Karolinska Institutet in Stockholm. more

Infographics Autophagy

Nobel Prize in Physiology or Medicine 2016

In 2016 the Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi for discovering the mechanisms of autophagy. more

Publications Autophagy

• Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking [Biochemistry]

  Beclin 1 is an essential autophagy protein. Through its coiled-coil domain, Beclin 1 recruits two modulators, Atg14L and UVRAG, to form Atg14L- or UVRAG-containing Beclin 1–Vps34 subcomplexes responsible for Vps34-dependent membrane trafficking processes including autophagy and endosomal trafficking more

• RNA processing for metabolic control

  Metabolism Autophagy is a cellular response to nutrient starvation that allows cells to recycle existing molecules and organelles. Tang et al. investigated the mechanisms by which TORC1 (target of rapamycin complex 1) regulates autophagy. They discovered that regulation occurs through control of RNA more

• Marine Drugs, Vol. 16, Pages 204: Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the ...

  Marine Drugs, Vol. 16, Pages 204: Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hsp90 Marine Drugs doi: 10.3390/md16060204 Authors: Man-Gang Lee Yi-Chang Liu more