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Takara Bio Europe is a wholly owned subsidiary of Takara Bio Inc., who develops, manufactures, and distributes a wide range of life science reagents under the Takara™, Clontech®, and Cellartis® brands. Key products include SMART cDNA synthesis kits for a variety of samples and applications, includ more
Merck Millipore is the Life Science division of Merck KGaA of Germany and offers a broad range of innovative, performance products, services and business relationships that enable our customers’ success in research, development and production of biotech and pharmaceutical drug therapies. Through ded more
BlueRock Therapeutics is a leading engineered cell therapy company with a mission to develop regenerative medicines for intractable diseases. BlueRock Therapeutics’ CELL+GENE™ platform harnesses the power of cells for new medicines across neurology, cardiology and immunology indications. BlueRock Th more
Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia. However, the side effects of therapies are often severe. A group of researchers led by the University of Zurich have now shown how human healthy and cancerous hematopoietic stem cells can be more selective more
A lipid metabolism enzyme controls brain stem cell activity and lifelong brain development. If the enzyme does not work correctly, it causes learning and memory deficits in humans and mice, as researchers at the University of Zurich have discovered. Regulating stem cell activity via lipid metabolism more
The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor pancreases are rare. In a new study, a group of researchers developed an improved pluripotent stem cell differentiation proto more
An MRI shows stem cells labeled with iron oxide nanoparticles being injected into an animal’s brain. more
Researchers at Columbia University Medical Center have developed three-dimensional lung bud "organoids" from human pluripotent stem cells. The "mini organs" could be used to model lung diseases such as pulmonary fibrosis and respiratory syncytial virus infection.The research was carried out in t ... more
By using array-based sequence capture and pyrosequencing to sequence an allelic series from the classically defined Kit locus (~200 kb) from each of five noncomplementing Kit mutants (one known allele and four unknown alleles), D'Ascenzo and co-worke more
Automated monitoring and data collection contribute to significant time savings when using the xCELLigence System, with only a few minutes of extra setup time. For example, in a 96-well plate, 32 different conditions can be tested in triplicate; the more
A key observation in these presented results was the magnitude of hypermethylation in PC3 cells, which occurred at almost all of the inactive CpG island genes. A second key observation was that when PRC marks were depleted, a PC3 hypermethylation was more
The stem cell niche is a specialized environment that dictates stem cell function during development and homeostasis. We show that Dll1, a Notch pathway ligand, is enriched in mammary gland stem cells (MaSCs) and mediates critical interactions with stromal macrophages in the surrounding niche in mo more
Stem Cells Macrophages engulf damaged and dead cells to clear infection, but they also participate in tissue regeneration. Chakrabarti et al. expand the macrophage repertoire for mammary gland development (see the Perspective by Kannan and Eaves). Mammary gland stem cells secrete the Notch ligand more
The adult mammary gland is a bilayered branching epithelial structure consisting of an outer layer of basal cells and an inner layer of luminal cells. The neonatal structure expands rapidly during puberty and then undergoes cyclic growth in response to the changing hormonal stimuli (progesterone and more
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