Adenovirus

Companies Adenovirus

SIRION BIOTECH GmbH, Germany

SIRION Biotech is Europe's leading commercial supplier of viral vectors used for genetic cell modelling, gene target validation and gene therapy- and vaccination studies. Since its foundation in 2007, SIRION’s mission has been to change the paradigm for viral vector supplies. It has the ability to more

News Adenovirus

• Engineering a cancer-fighting virus
  

  An engineered virus kills cancer cells more effectively than another virus currently used in treatments, according to Hokkaido University researchers. Hokkaido University researchers have engineered a virus that selectively targets and kills cancer cells. The virus, called dl355, has an even stronge more

• Stealth Virus for Cancer Therapy
  

  Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect more

• Attacking tumors from the inside
  

  The targeted delivery of drugs directly into cancer cells is becoming an increasingly common method of ensuring more accurate, safer cancer treatments. Scientists are now exploring the concept of using specially-created groups of immune cells to carry biologics – drugs derived from natural sources s more

Publications Adenovirus

• Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA combined with cisplatin inhibits cellular growth and induces apoptosis in HPV-positive head and neck cancer cells

  Human papillomavirus (HPV) infection has been identified as an etiologic factor of head and neck cancers (HNCs). We explored the potential use of antisense HPV RNA transcripts for gene therapy and its effect in combination with cisplatin (CDDP) for HPV-positive HNCs. We introduced the antisense RNA more

• Role of kinesins in directed adenovirus transport and cytoplasmic exploration

  by Jie Zhou, Julian Scherer, Julie Yi, Richard B. Vallee Many viruses, including adenovirus, exhibit bidirectional transport along microtubules following cell entry. Cytoplasmic dynein is responsible for microtubule minus end transport of adenovirus capsids after endosomal escape. However, the id more

• Hyaluronan negatively regulates vascular calcification involving BMP2 signaling

  Vascular calcification is a highly regulated biological process similar to bone formation involving osteogenic differentiation of vascular smooth muscle cells (VSMCs). Hyaluronan (HA), a major structural component of the extracellular matrix in cartilage, has been shown to inhibit osteoblast differe more