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A new cellular garbage control pathway with relevance for human neurodegenerative diseases

Several human neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s disease but also ageing, are linked to an accumulation of abnormal and aggregated proteins in cells. Cellular “garbage” can be removed from cells by sweeping them to a cellular recycling station kn ... more

Preventing foodborne illness, naturally - with cinnamon

Seeking ways to prevent some of the most serious foodborne illnesses caused by pathogenic bacteria, two Washington State University scientists have found promise in an ancient but common cooking spice: cinnamon. Recent findings published in Food Control suggest Cinnamomum cassia oil can wor ... more

Scientists map one of most important proteins in life - and cancer

Scientists reveal the structure of one of the most important and complicated proteins in cell division – a fundamental process in life and the development of cancer – in research published in Nature. Images of the gigantic protein in unprecedented detail will transform scientists' understan ... more

Decoding dengue

Scientists have discovered a new pathway the dengue virus takes to suppress the human immune system. This new knowledge deepens our understanding of the virus and could contribute to the development of more effective therapeutics. For years, the conventional approach to target the dengue vi ... more

Crenezumab Phase II cognition data in Alzheimer’s disease presented

AC Immune announced the presentation of data from two phase II studies investigating whether crenezumab (anti beta-amyloid antibody) can delay cognitive and functional decline in people with mild-to-moderate Alzheimer’s disease (AD) by its partner Genentech, a member of the Roche Group. The ... more

PBL awared further US patents on short RNAi molecules

Plant Bioscience Limited (PBL) announced that the United States Patent and Trademark Office (USPTO) has issued US Patent No. 8,759,102 and US Patent No. 8,779,236 with fundamental claims directed to RNAi in cells and organisms to effect gene silencing. These two new patents granted add to t ... more

Ötzi’s “non-human” DNA

Ötzi’s human genome was decoded from a hip bone sample taken from the 5,300 year old mummy. However the tiny sample weighing no more than 0.1 g provides so much more information. A team of scientists from EURAC in Bolzano/Bozen together with colleagues from the University of Vienna successf ... more

Santhera Repositions Omigapil in Congenital Muscular Dystrophy

Santhera Pharmaceuticals announced the initiation of a clinical program with omigapil, a drug candidate in-licensed from Novartis and repositioned for therapeutic use in Congenital Muscular Dystrophy (CMD). The clinical development program will be initiated with a Phase I study in pediatric ... more

One injection stops diabetes in its tracks

—In mice with diet-induced diabetes— the equivalent of type 2 diabetes in humans —a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. The discovery by Salk scientists, published today in the journal Nature, could lead to ... more

immatics receives €22 million final tranche of Series D fundraising

immatics biotechnologies GmbH announced that it has received €22m to complete a Series D financing round. The Company received €12m in October 2013 as an initial tranche of the total €34m funding round. The Series D funding was supported by existing investors including dievini Hopp Biotech ... more

All news

Ötzi’s “non-human” DNA

Ötzi’s human genome was decoded from a hip bone sample taken from the 5,300 year old mummy. However the tiny sample weighing no more than 0.1 g provides so much more information. A team of scientists from EURAC in Bolzano/Bozen together with colleagues from the University of Vienna successf ... more

Pseudogenes may provide clearer understanding of biomarkers

Alas, the thankless pseudogene. Dysfunctional, unloved and seemingly of little use, these poor-cousin relatives of genes have lost their protein-coding abilities. They contain material not essential for an organism's survival and are the "last stop" for removal of genomic waste. Not any mor ... more

Identifying microbial species

Millions of microbial species populate the world, but so far only a few have been identified due to the inability of most microbes to grow in the laboratory. Edgar Goluch, an engineer, and Slava Epstein, a biologist, aim to change this. The pair, both researchers at Northeastern University, ... more

Prototype electrolyte sensor to provide immediate read-outs

Patients trying to navigate today's complex medical system with its costly laboratory analyses might prefer a pain-free home diagnostic device, worn on the wrist, that can analyze, continuously record and immediately remedy low electrolyte levels.Runners, athletes in other strenuous sports ... more

Agilent Technologies Thought Leader Award Supports Dr. Carolyn Mountford

Agilent Technologies Inc. announced that Dr. Carolyn Mountford has received an Agilent Thought Leader Award in recognition of her work using nuclear magnetic resonance (NMR) spectroscopy technology in cancer research.Dr. Mountford is a professor of radiology at The University of Newcastle A ... more

analytica closes with outstanding results in all areas

Despite a pilot strike, visitors from around the world flocked to the trade-fair center in Munich during the past four days. The reason: the 24th analytica. The trade fair for laboratory technology, analysis and biotechnology attracted more than 34,400 visitors to Munich (compared to 30,481 ... more

Tracing how the embryo takes over

Embryonic development is initially controlled by maternal genetic information stored in the egg. LMU researchers now describe a methodology that allows the succeeding activation of the zygotic genome to be mapped at high resolution. In multicellular organisms, the earliest steps in embryoni ... more

analytica 2014 to focus on food and plastics analysis, genetic analysis and bioanalysis

A first-rate and exciting program of events awaits visitors at the 24th analytica in Munich. From April 1 – 4, the International Trade Fair for Laboratory Technology, Analysis and Biotechnology will once again be a center for key players in science and industry. More than 1,100 exhibitors w ... more

MolecularHealth Partners with GATC Biotech for Genetic Sequencing Technology and Expertise

MolecularHealth announced a unique agreement with GATC Biotech. GATC Biotech will provide protocols, support and extensive training of MolecularHealth’s laboratory staff. Additionally, MolecularHealth will use GATC Biotech’s LIMS (Laboratory Information Management System) in itsnewly opened ... more

Neandertal genome project reaches its goal

An international research team led by Kay Prüfer and Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, has determined a high-quality genome sequence of a Neandertal woman. The genome allows detailed insights into the relationships and population his ... more

All news on bioanalytics

Scientists map one of most important proteins in life - and cancer

Scientists reveal the structure of one of the most important and complicated proteins in cell division – a fundamental process in life and the development of cancer – in research published in Nature. Images of the gigantic protein in unprecedented detail will transform scientists' understan ... more

Decoding dengue

Scientists have discovered a new pathway the dengue virus takes to suppress the human immune system. This new knowledge deepens our understanding of the virus and could contribute to the development of more effective therapeutics. For years, the conventional approach to target the dengue vi ... more

PBL awared further US patents on short RNAi molecules

Plant Bioscience Limited (PBL) announced that the United States Patent and Trademark Office (USPTO) has issued US Patent No. 8,759,102 and US Patent No. 8,779,236 with fundamental claims directed to RNAi in cells and organisms to effect gene silencing. These two new patents granted add to t ... more

immatics receives €22 million final tranche of Series D fundraising

immatics biotechnologies GmbH announced that it has received €22m to complete a Series D financing round. The Company received €12m in October 2013 as an initial tranche of the total €34m funding round. The Series D funding was supported by existing investors including dievini Hopp Biotech ... more

Siemens Healthcare agrees to sell microbiology business to Beckman Coulter

Siemens Healthcare is selling its microbiology business to Beckman Coulter Inc., a wholly owned subsidiary of Danaher Corporation. The activities of the microbiology business include systems for the identification and antibiotic susceptibility testing (ID/AST) of microorganisms. The decisio ... more

A Sweet Pathway into the Cell

How do bacteria overcome the barrier of the outer membrane to gain access to the cells of the body? That is the question addressed by junior professor Dr. Winfried Roemer and his colleagues Kevin Troendle and Dr. Julie Claudinon from the Institute of Biology II, members of the Cluster of Ex ... more

Antibody halts cancer-related wasting condition

New research raises the prospect of more effective treatments for cachexia, a profound wasting of fat and muscle occurring in about half of all cancer patients, raising their risk of death, according to scientists from Dana-Farber Cancer Institute. Many strategies have been tried to reverse ... more

Parkinson‘s disease: genetic defect triggers multiple damages in neurons

People whose genome carries certain variations have a particularly high risk of developing Parkinson's disease. In particular, genetic variants in a gene referred to as GBA1 (glucocerebrosidase) are associated to an increased risk for Parkinson’s. Researchers of the German Center for Neurod ... more

CryoLife Appoints Pat Mackin as President and Chief Executive Officer

CryoLife, Inc. announced that its Board of Directors has appointed James Patrick (Pat) Mackin, age 47, as President and Chief Executive Officer, effective September 2, 2014. Mr. Mackin is expected to be appointed to the Company's Board of Directors after his employment begins.Steven G. Ande ... more

No extra mutations in modified stem cells, study finds

The ability to switch out one gene for another in a line of living stem cells has only crossed from science fiction to reality within this decade. As with any new technology, it brings with it both promise - the hope of fixing disease-causing genes in humans, for example - as well as questi ... more

All news on biotechnology

New blood test identifies risk “Sudden Cardiac Death”

UAntwerp (University of Antwerp), UZA (Antwerp University Hospital), and Multiplicom NV together developed a blood test to determine the genetic risk of “Sudden Cardiac Death” (SCD). This test, called PED MASTR, is already in use at the center of medical genetics of UZA/UAntwerp and will be ... more

Merck to Collaborate with Sysmex Inostics on a Blood-Based RAS Biomarker Test

Merck announced that the company has signed an agreement to collaborate with Sysmex Inostics GmbH for the development and commercialization of a blood-based RAS biomarker test for patients with metastatic colorectal cancer (mCRC). Blood-based biomarker testing is a faster and easier approac ... more

Studies Validate EKF Diagnostics’ Early Stage Test for Progressive Diabetic Kidney Disease

EKF Diagnostics confirmed the growing weight of independent scientific evidence as validation that soluble TNF Receptors 1 and 2 are strong biomarkers of progressive Diabetic Kidney Disease (DKD). EKF affirms that the markers can be reliably used as diagnostic tests to predict end-stage ren ... more

Research that more than meets the eye

The link between blood flow in the retina and the development of glaucoma can now be measured accurately for the first time. This was made possible by the further development of an established measurement method, optical coherence tomography (OCT), which enables the visual assessment of the ... more

Research combines graphene and painkiller receptor

Almost every biological process involves sensing the presence of a certain chemical. Finely tuned over millions of years of evolution, the body’s different receptors are shaped to accept certain target chemicals. When they bind, the receptors tell their host cells to produce nerve impulses, ... more

Exact outline of melanoma could lead to new diagnostic tools

Researchers at Oregon State University have identified a specific biochemical process that can cause normal and healthy skin cells to transform into cancerous melanoma cells, which should help predict melanoma vulnerability and could also lead to future therapies. More than 70,000 cases of ... more

First living organism that transmits added letters in DNA 'alphabet'

Scientists at The Scripps Research Institute (TSRI) have engineered a bacterium whose genetic material includes an added pair of DNA "letters," or bases, not found in nature. The cells of this unique bacterium can replicate the unnatural DNA bases more or less normally, for as long as the m ... more

Electronic Nose Sniffs Out Prostate Cancer

We may soon be able to make easy and early diagnoses of prostate cancer by smell. Investigators in Finland have established that a novel noninvasive technique can detect prostate cancer using an electronic nose. In a proof of principle study, the eNose successfully discriminated between pro ... more

Emerging technologies redefine infectious disease diagnostics

The diagnostics market for infectious diseases such as tuberculosis (TB), human immunodeficiency virus (HIV), hepatitis C virus and human papilloma virus is expanding, giving rise to commercial opportunities especially in the developing economies of Asia, Africa and Latin America. The urgen ... more

Evotec receives first milestone in Roche biomarker collaboration

Evotec AG announced the successful achievement of a milestone in its biomarker alliance with Roche. The milestone was achieved on the decision by Roche to use a response prediction marker, identified using Evotec's Proteome Profiling platform, in an extended phase I oncology trial. This is ... more

All news on diagnostics

Merger of CyBio AG into Analytik Jena AG Completed

The merger of CyBio AG into Analytik Jena AG became effective upon entry into the commercial register of Analytik Jena AG (commercial register of the Registry Court of Jena, HRB 200027). As a result, CyBio AG is dissolved as an independent company. In the future, the Life Science business u ... more

LABVOLUTION – the new lab technology show in Hannover

Deutsche Messe is launching LABVOLUTION, a new trade fair to be staged every two years as amajor platform for the world of lab technology and equipment. LABVOLUTIONmakes its debut from 6 to 8 October 2015 at the Hannover Exhibition Center in Hannover, Germany, where it will take place every ... more

Automating Laboratory-On-A-Chip To Cut Healthcare Costs

A research team at the University of California, Riverside has created a computer programming language that will automate “laboratory-on-a-chip” technologies used in DNA sequencing, drug discovery, virus detection and other biomedical applications.“If you think of the beginning of computers ... more

Reorganization of the Executive Board of Eppendorf AG

The Executive Board of Eppendorf AG is reshaping in order to be optimally equipped to meet the future demands of the market. Dr. Dirk Ehlers, Chairman of the Executive Board of the Eppendorf Group, will leave the company by mutual agreement. Detmar Ammermann (Chief Financial Officer) will r ... more

New microscope sees what others can't

Microscopes don't exactly lie, but their limitations affect the truths they can tell. For example, scanning electron microscopes (SEMs) simply can't see materials that don't conduct electricity very well, and their high energies can actually damage some types of samples. In an effort to ext ... more

A lab in your pocket

When you get sick, your physician may take a sample of your blood, send it to the lab and wait for results. In the near future, however, doctors may be able to run those tests almost instantly on a piece of plastic about the size of credit card. These labs-on-a-chip would not only be quick— ... more

Sartorius with Gains

Sartorius got off to a good start in fiscal 2014, with gains in order intake and sales revenue. In constant currencies, Group sales revenue rose 6.3% and order intake increased 4.9%. Despite negative currency impacts, operating Profit for the Group also grew 2.0%; its respective margin afte ... more

Turning smart phones into microscopes

Australian scientists have invented a simple and cheap way of making a high-powered lens that can transform a smart phone into a high-resolution microscope. Costing less than a cent, the lenses promise a revolution in science and medicine in developing countries and remote areas. The lens f ... more

analytica Vietnam 2015: Vietnam's economy continues to grow

According to Germany Trade & Invest (GTAI), the German association for foreign investment and location marketing, Vietnam plans to become a modern industrial nation by the year 2020. In addition, the southeast Asian threshold country is currently negotiating free trade agreements, amongst o ... more

Eppendorf: Sales stable in 2013

In fiscal year 2013, the Eppendorf Group achieved sales of €502.7 million (prior year: €520.2 million). When adjusted for currency effects, sales were only slightly lower than in the previous year (-0.4%). Income from operations (EBIT) decreased to €93.8 million (prior year: €101.5 million) ... more

All news on lab technology

Preventing foodborne illness, naturally - with cinnamon

Seeking ways to prevent some of the most serious foodborne illnesses caused by pathogenic bacteria, two Washington State University scientists have found promise in an ancient but common cooking spice: cinnamon. Recent findings published in Food Control suggest Cinnamomum cassia oil can wor ... more

Crenezumab Phase II cognition data in Alzheimer’s disease presented

AC Immune announced the presentation of data from two phase II studies investigating whether crenezumab (anti beta-amyloid antibody) can delay cognitive and functional decline in people with mild-to-moderate Alzheimer’s disease (AD) by its partner Genentech, a member of the Roche Group. The ... more

Santhera Repositions Omigapil in Congenital Muscular Dystrophy

Santhera Pharmaceuticals announced the initiation of a clinical program with omigapil, a drug candidate in-licensed from Novartis and repositioned for therapeutic use in Congenital Muscular Dystrophy (CMD). The clinical development program will be initiated with a Phase I study in pediatric ... more

One injection stops diabetes in its tracks

—In mice with diet-induced diabetes— the equivalent of type 2 diabetes in humans —a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. The discovery by Salk scientists, published today in the journal Nature, could lead to ... more

Novartis to license Google "smart lens" technology

Novartis announced that its eye care division Alcon has entered into an agreement with a division of Google Inc. to in-license its "smart lens" technology for all ocular medical uses. The agreement with Google[x], a team within Google that is devoted to finding new solutions to big global p ... more

Merck Serono Appoints Luciano Rossetti as Global Head of R&D

Merck Serono, the biopharmaceutical division of Merck, announced the appointment of Luciano Rossetti, M.D., as Executive Vice President and Global Head of Research & Development as of July 21, 2014. In his most recent role Rossetti (57) acted as Senior Vice President Late Stage Development ... more

Abbott to Sell its Developed Markets Branded Generics Pharmaceuticals Business to Mylan

Abbott announced that it will sell its developed markets branded generics pharmaceuticals business to Mylan for equity ownership of a newly formed entity that will combine Mylan's existing business and Abbott's developed markets pharmaceuticals business, and will be a publicly traded compan ... more

Transition Therapeutics Appoints Carl Damiani as Chief Operating Officer

Transition Therapeutics Inc. Chairman and Chief Executive Officer, Dr. Tony Cruz announced that Carl Damiani has been appointed to the role of Chief Operating Officer of Transition. "This appointment reflects Mr. Damiani's broader leadership role in overseeing Transition employees and opera ... more

Association between certain pain relievers and heart attack

For women taking certain kinds of pain relievers, a heart attack could be waiting in their medicine cabinets.  A University of Florida study has found that the regular use of some non-steroidal anti-inflammatory drugs, or NSAIDs, increases the risk of stroke, heart attack and death in postm ... more

Pharmalink's core patents for Nefecon treatment for renal disease granted

Pharmalink AB has had core patents for its late-stage clinical candidate Nefecon® issued in the key markets United States, Europe, China and Hong Kong. A patent is pending in Japan. Nefecon is a potential disease-modifying treatment for patients with primary IgA nephropathy at risk of devel ... more

All news on pharma

Scientists map one of most important proteins in life - and cancer

Scientists reveal the structure of one of the most important and complicated proteins in cell division – a fundamental process in life and the development of cancer – in research published in Nature. Images of the gigantic protein in unprecedented detail will transform scientists' understan ... more

Decoding dengue

Scientists have discovered a new pathway the dengue virus takes to suppress the human immune system. This new knowledge deepens our understanding of the virus and could contribute to the development of more effective therapeutics. For years, the conventional approach to target the dengue vi ... more

How antioxidants can accelerate cancers, and why they don't protect against them

For decades, health-conscious people around the globe have taken antioxidant supplements and eaten foods rich in antioxidants, figuring this was one of the paths to good health and a long life. Yet clinical trials of antioxidant supplements have repeatedly dashed the hopes of consumers who ... more

Antibody halts cancer-related wasting condition

New research raises the prospect of more effective treatments for cachexia, a profound wasting of fat and muscle occurring in about half of all cancer patients, raising their risk of death, according to scientists from Dana-Farber Cancer Institute. Many strategies have been tried to reverse ... more

Parkinson‘s disease: genetic defect triggers multiple damages in neurons

People whose genome carries certain variations have a particularly high risk of developing Parkinson's disease. In particular, genetic variants in a gene referred to as GBA1 (glucocerebrosidase) are associated to an increased risk for Parkinson’s. Researchers of the German Center for Neurod ... more

Huntington's disease protein helps wire the young brain

The protein that is mutated in Huntington's disease is critical for wiring the brain in early life, according to a new Duke University study. Huntington's disease is a progressive neurodegenerative disorder that causes a wide variety of symptoms, such as uncontrolled movements, inability to ... more

HIV study leads to insights into deadly infection

Research led by the University of Adelaide has provided new insights into how the HIV virus greatly boosts its chances of spreading infection, and why HIV is so hard to combat. HIV infects human immune cells by turning the infection-fighting proteins of these cells into a "backdoor key" tha ... more

Merck Serono Announces Global Grants Program to Fund Scientific Innovation

Merck Serono, the biopharmaceutical division of Merck, announced the launch of Merck Global Grants – a program that underscores the company’s commitment to funding scientific innovation and independent medical education around the world. The initiative encompasses Merck Serono’s complete gr ... more

Contradictory Findings about the Effect of the Full Moon on Sleep

According to folklore, the full moon affects human sleep. International researchers are trying to determine whether there is any truth to the belief. Studies by a team at The University of Gothenburg in Sweden have found that people actually sleep 20 minutes less when the moon is full. A Sw ... more

Gene mutation may lead to treatment for liver cancer

Two genetic mutations in liver cells may drive tumor formation in intrahepatic cholangiocarcinoma (iCCA), the second most common form of liver cancer, according to a research published in the July issue of the journal Nature. A team led by the Icahn School of Medicine at Mount Sinai and Har ... more

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