Researchers have found that salicylic acid targets the activities of HMGB1, an inflammatory protein associated with a wide variety of diseases, offering hope that more powerful aspirin-like drugs may be developed.
Aspirin is one of the oldest and most commonly used medicines, but many of it ... more
A multicenter study of young patients with bipolar disorder provides what may be the most scientifically rigorous demonstration to date that lithium can also be safe and effective for children suffering from it.
The study, led by a researcher at the Johns Hopkins Children's Center affirms w ... more
In cooperation with colleagues in Munich and Göttingen, researchers at the German Center for Neurodegenerative Diseases (DZNE) in Bonn have analyzed a novel substance that could serve as a prototype for the development of drugs to treat Alzheimers and other brain diseases. Known as anle138b ... more
Merck and Pfizer announced that the US Food and Drug Administration (FDA) has granted avelumab, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, Fast Track designation for the treatment of metastatic Merkel cell carcinoma (MCC), a rare and aggressive type of skin cancer. ... more
The human organism is composed of numerous types of molecules, both simple and complex, and all fundamental processes in a living body occur in water solutions. Therefore, for a drug to work, it must dissolve in body liquids, which are primarily water. Polymorphism of solid substances, a we ... more
Researchers at UC Santa Cruz have determined the structure of a key part of the enzyme telomerase, which is active in most cancers and enables cancer cells to proliferate indefinitely. The new findings reveal how the enzyme carries out a crucial function involved in protecting the ends of c ... more
Evotec AG announced it has entered into a multi-year compound management agreement with the U.S. National Cancer Institute (NCI), Department of Health and Human Services. Under the terms of the agreement, Evotec will provide compound management services to the NCI Chemical Biology Consortiu ... more
Can you imagine a drug that would make it easier to learn a language, sharpen your memory and help those with dementia and Alzheimer's disease by rewiring the brain and keeping neurons alive?
New Rutgers research found that a drug - RGFP966 - administered to rats made them more attuned to w ... more
Malaria was traditionally treated by chloroquine or quinine, but with declining success. By the late 1960s, efforts to eradicate Malaria had failed and the disease was on the rise. At that time, Youyou Tu in China turned to traditional herbal medicine to tackle the challenge of developing n ... more
After decades of limited progress in developing durable therapies for parasitic diseases, the discoveries by this year’s Laureates radically changed the situation.
Satoshi Ōmura, a Japanese microbiologist and expert in isolating natural products, focused on a group of bacteria, Streptomyces ... more