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Superficial spreading melanoma
Superficial spreading melanoma (SSM) is the most common form of cutaneous melanoma in Caucasians. The average age at diagnosis is in the fifth decade, and it tends to occur on sun-exposed skin, especially on the backs of males and lower limbs of females.
Often, this disease evolves from a precursor lesion, usually a dysplastic nevus. Otherwise it arises in previously normal skin. A prolonged radial growth phase, where the lesion remains thin, may eventually be followed by a vertical growth phase where the lesion becomes thick and nodular. As the risk of spread varies with the thickness, early SSM is more frequently cured than late nodular melanoma.
The microscopic hallmarks are:
Treatment is by excisional biopsy, wide local excision and possibly sentinel node biopsy. Spread of disease to local lymph nodes or distant sites (typically brain, bone, skin and lung) marks a decidedly poor prognosis.Cholangiocarcinoma - Hepatocellular adenoma/Hepatocellular carcinoma - Adenoid cystic carcinoma - Familial adenomatous polyposis - Prolactinoma - Oncocytoma - Hurthle cell - Clear cell adenoma/adenocarcinoma - Renal cell carcinoma - Multiple endocrine neoplasia - Endometrioid tumor
|Adnexal And Skin appendage (8390-8429)||sweat gland (Hidrocystoma, Syringoma)|
|Cystic, Mucinous And Serous (8440-8499)||(Mucoepidermoid carcinoma - Cystadenoma/Cystadenocarcinoma/Pseudomyxoma peritonei - Signet ring cell carcinoma/Krukenberg tumor|
|Ductal, Lobular And Medullary (8500-8549)||Ductal carcinoma - Paget's disease of the breast/Extramammary Paget's disease|
|Acinar cell (8550-8559)||Acinic cell carcinoma|
|Complex epithelial (8560-8589)||Warthin's tumor - Thymoma|
|Gonadal (8590-8679)||Sex cord-stromal tumour - Thecoma - Granulosa cell tumour - Arrhenoblastoma/Sertoli-Leydig cell tumour|
|Paragangliomas And Glomus tumors (8680-8719)||Paraganglioma - Pheochromocytoma - Glomus tumor|
|Nevi and melanomas (8720-8799)||Melanocytic nevus - Nodular melanoma - Dysplastic nevus - Lentigo maligna melanoma - Superficial spreading melanoma - Blue nevus|