Adenovirus

Companies Adenovirus

SIRION BIOTECH GmbH, Germany

SIRION BIOTECH is a technology leader in the field of functional gene analysis and cell models for basic research, drug and compound development. The company serves leading European and Japanese Drug and Biotech companies as a provider of latest technologies for them to advance identification of nov more

News Adenovirus

• ORCA Therapeutics Receives up to € 5 Million Innovation Credit from Dutch Government

  ORCA Therapeutics BV announced that it has received an innovation credit of up to € 5 million from Agentschap NL, an agency executing programmes for the Dutch Ministry of Economic Affairs, Agriculture and Innovation, to support development of its lead compound ORCA-010 for prostate cancer.The innova more

• Cell Medica strengthens team with key appointment to senior management

  Cell Medica has announced that is has appointed four key staff to drive forwards the Company’s activities in the commercialisation of cell therapy treatments. The appointments will enable the Company to achieve scale up of its cell manufacturing operations, increase its clinical development capabili more

• Crucell HIV Vaccine: Promising Preliminary Results Phase I Study

  Crucell N.V. announced that preliminary results of the Phase I study of its HIV vaccine were presented at La Conférence AIDS Vaccine 2009 in Paris, France. The presentation was given by Dr Dan H. Barouch, MD, PhD, Associate Professor of Medicine, Division of Vaccine Research, Department of Medicin more

White papers Adenovirus

• Efficacy Comparison of Transfection Reagents in a Collecting Duct Cell Line
  

  The cortical collecting duct regulates ion and water homeostasis in the kidney. A cell line denoted M-1 has been established from the cortical collecting duct of a transgenic mouse that exhibits many functional properties of the original tissue. While this cell line is valuable for in vitro studies, the cells are not easily transfected. Frequently, adenovirus-mediated gene transfer is used. As adenovirus production requires several additional steps, we prefer chemical methods to achieve recombinant protein expression in M-1 cells. Previous attempts to transfect this cell line were unsuccessful with far less than 10% of transfectants, although different reagents were tried. Here we compare three commercially available transfection reagents in terms of the percentage of transfected cells and the suitability for using a reporter construct in M-1 cells. more

• Optimization of Transfection Efficiency in Chick Embryo Hepatocytes and HepG2 Cells
  

  Cell and molecular biology studies have been facilitated by transfection, a technology that can deliver material like DNA, RNA, and protein into cells. However, there are multiple reagents on the market, and a careful study must be perform­ed in order to find a suitable technique for your particular cellular system. One of the most effective re-agents that was available on the market in the early 90's was DOTMA (N-[1-(2,3-dioleyloxy)propyl]-N,N,N-tri-methylammonium chloride). more

Publications Adenovirus

• Antihypoxia effect of adenovirus‐mediated expression of heat shock protein 70 (HSP70) on primary cultured neurons

  Heat shock protein 70 (HSP70) has attracted great attention recently in hypoxia injury because of its close link to the recovery after hypoxic–ischemic damage in organs. However, the cellular mechanism underlying its protective roles remains unclear. In this study, we developed a recombinant adeno more

• E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways [Cell Biology]

  The adenovirus E4orf4 protein regulates the progression of viral infection, and when expressed alone in mammalian tissue culture cells it induces protein phosphatase 2A (PP2A)-B55– and Src-dependent cell death, which is more efficient in oncogene-transformed cells than in normal cells. This form of more

• The adenovirus VA RNA-derived miRNAs are not essential for lytic virus growth in tissue culture cells

  At late times during a lytic infection human adenovirus type 5 produces ~108 copies per cell of virus-associated RNA I (VA RNAI). This short highly structured RNA polymerase III transcript has previously been shown to be essential for lytic virus growth. A fraction of VA RNAI is processed by Dicer more

Market studies Adenovirus

• Adenovirus Infections Global Clinical Trials Review, H1, 2012

  Introduction GlobalData's clinical trial report, “Adenovirus Infections Global Clinical Trials Review, H1, 2012" provides data on the Adenovirus Infections clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Adenovirus Infections. It incl more

• Adenovirus Infections – Pipeline Review, H1 2012

  Introduction Global Markets Direct’s, 'Adenovirus Infections - Pipeline Review, H1 2012', provides an overview of the Adenovirus Infections therapeutic pipeline. This report provides information on the therapeutic development for Adenovirus Infections, complete with latest updates, and special fea more

• Clinical Trial Endpoints in Oncology - Inclusion of Surrogate Endpoints and Shorter Endpoints Will Ensure Faster Clinical Trials in Oncology

  GBI Research, the leading business intelligence provider, has released its latest research “Clinical Trial Endpoints in Oncology – Inclusion of Surrogate Endpoints and Shorter Endpoints will Ensure Faster Clinical Trials in Oncology”, which essentially provides insights into clinical trial endpoints more

Websites Adenovirus