Biostat STR®

The Biostat STR® Generation 3 single-use bioreactor system represents a sophisticated bioprocessing solution engineered to deliver exceptional performance across diverse manufacturing applications. Powered by the Biobrain® automation platform, this advanced system provides comprehensive process control capabilities while maintaining the flexibility to adapt to evolving production requirements.

The system's modular architecture features interchangeable bagholders that accommodate working volumes from 12.5 L to 2,000 L, enabling seamless scalability from process development through commercial manufacturing. The geometric similarity across the bioreactor portfolio facilitates predictable scale-up transitions, reducing development timelines and minimizing technical risks.

Enhanced with integrated Repligen XCell ATF® Technology, the platform supports process intensification strategies that can significantly increase cell densities and productivity. The Flexsafe STR® bags incorporate optimized resin formulations and minimized additive packages, contributing to improved cell viability and enhanced product quality consistency.

The comprehensive BioPAT® analytical toolbox provides real-time monitoring capabilities including viable biomass measurement, glucose and lactate monitoring, and advanced foam detection systems. These process analytical technologies enable precise process control and automated feeding strategies that optimize product yield and quality.

The GMP-compliant Biobrain® automation platform delivers advanced functionalities including local recipe execution, comprehensive data archiving, audit trail capabilities, and batch reporting features. The system supports industry standards including GAMP 5, ISA 88, and OPC UA protocols, ensuring seamless integration with existing facility infrastructures.

From monoclonal antibodies and biosimilars to plasmid DNA, mRNA, and vaccine production, the versatile platform accommodates numerous therapeutic modalities. The system supports various process strategies ranging from classical batch operations to intensified perfusion processes, providing manufacturers with the operational flexibility required for diverse production scenarios.