Biostat® RM

The Biostat® RM rocking motion bioreactor system delivers a comprehensive solution for cell culture applications ranging from seed expansion to commercial manufacturing. This GMP-compliant wave-mixing technology accommodates volumes from 1 L to 200 L, making it uniquely suitable for both product development and manufacturing scale operations.

The system's gentle rocking motion provides optimal conditions for shear-stress-sensitive cell lines including CHO, NS0, Sf9, E. coli, stem cells, and CAR-T cells, while maintaining precise process control throughout cultivation. The technology proves particularly beneficial for bioconjugate production where traditional mixing methods may compromise product integrity.

Central to the system's value proposition is the Biobrain® automation platform, which creates a unified operating environment from development through commercial manufacturing. This shared platform eliminates the need for system changeovers during scale-up, reducing operator training requirements and minimizing transfer-related risks. The intuitive interface guides users through all processes, supporting both experienced operators and those new to the technology.

The modular equipment concept enables flexible workspace configurations, allowing the same platform to accommodate different tray sizes (20 L or 50 L) and various Flexsafe® RM bag configurations including basic, optical, and perfusion setups. This adaptability supports both classic fed-batch and intensified processes within a single production seed train.

Key technical capabilities include advanced dissolved oxygen control, gravimetric feeding systems, and comprehensive process monitoring through integrated sensors for temperature, pH, and dissolved oxygen. The system's compact footprint optimizes laboratory space utilization while maintaining full functionality for complex bioprocessing requirements.

The Biostat® RM represents an integrated approach to bioreactor technology, combining proven rocking motion principles with commercial manufacturing-ready automation to accelerate time-to-market for biotechnology products across protein, vaccine, and cell and gene therapy applications.