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93 Current news about the topic dna repair

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Mutant protein tackles DNA guardian to promote cancer development

How tumour development is driven by mutations in important gene in preventing cancer

09-Nov-2018

Melbourne scientists have discovered how tumour development is driven by mutations in the most important gene in preventing cancer, p53. The research revealed that in the early stages of cancer, mutant p53 'tackles' the normal p53 protein and blocks it from carrying out its protective role. As a ...

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How resistant cancer cells can be fought

31-Jul-2018

An international research team under the co-direction of the University of Bern and the Netherlands Cancer Institute (NKI) has discovered various mechanisms of resistance to cancer therapy. The findings help researchers to understand the self-repair of cancer cells after a therapy and thus help ...

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A DNA 'shield' with crucial roles in normal cell division

20-Jul-2018

In immune cells, this is crucial to make antibodies In cancer, mutations in complex could lead to resistance to BRCA-targeting PARP inhibitor drugs or platinum chemotherapies Scientists have made a major discovery about how cells repair broken strands of DNA that could have huge implications for ...

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Less failure in CRIPSR gene editing

Biochemists discover cause of genome editing failures

13-Jul-2018

Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. CRISPR is a gene-editing tool that allows scientists to cut out unwanted genes or genetic material from DNA, ...

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Timing is key for bacteria surviving antibiotics

04-Jul-2018

For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment. When antibiotics hit a ...

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The world's tiniest first responders

'Walking molecules' haul away damaged DNA to the cell's emergency room

22-Jun-2018

The cell has its own paramedic team and emergency room to aid and repair damaged DNA, a new USC Dornsife study reveals. The findings are timely, as scientists are delving into the potential of genome editing with the DNA-cutting enzyme, CRISPR-Cas9, to treat diseases or to advance scientific ...

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Artificial gene defect reveals target to fight genetic disease

13-Jun-2018

DNA Repair is essential for a healthy organism. In every day of our lives, tens of thousands of damages occur in the genetic material of our cells. Hence, it is not surprising that a broad variety of repair mechanisms developed in the course of evolution that enables cells to quickly react and ...

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Dicer is not rolling dice

25-Apr-2018

Researchers keep discovering new functions of small RNAs. For instance, they can be used as a defense mechanism against viruses or self-replicating genome invaders. These tiny pieces of RNA are often produced by a cleavage of long precursors by so called Dicer proteins. To their surprise, ...

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How the most common DNA mutation happens

05-Feb-2018

Researchers describe how two normally mismatched bases in human DNA, guanine and thymine, are able to change shape in order to form an inconspicuous rung on the helical DNA "ladder." This allows them to survive by avoiding the body's natural defenses against genetic mutations. "When these two ...

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When the "guardian" and the "caretaker" of the genome join forces

Scientists decipher a biochemical mechanism significant for tumour biology

26-Jan-2018

Achievement in the field of cancer research: Biologists and chemists at the University of Konstanz decipher a molecular mechanism of the cell with relevance for the development of cancer and the fight against that disease. Particularly important is the interaction between the tumour-suppressor ...

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