NIH clinical trial of remdesivir to treat COVID-19 begins

27-Feb-2020 - A randomized, controlled clinical trial to evaluate the safety and efficacy of the investigational antiviral remdesivir in hospitalized adults diagnosed with coronavirus disease 2019 (COVID-19) has begun at the University of Nebraska Medical Center (UNMC) in Omaha. The trial regulatory sponsor is ...

Investigational monoclonal antibody to treat Ebola is safe in adults

28-Jan-2019 - The investigational Ebola treatment mAb114 is safe, well-tolerated, and easy to administer, according to findings from an early-stage clinical trial. Eighteen healthy adults received the monoclonal antibody as part of a Phase 1 clinical trial that began in May 2018 at the National Institutes of ...

QIAGEN acquires bioinformatics company

Expanding clinical bioinformatics capabilities in molecular oncology

08-Jan-2019 - QIAGEN N.V. announced it has entered into an agreement to acquire N-of-One, Inc., a privately-held U.S. molecular decision support company and pioneer in clinical interpretation services for complex genomic data. The addition of N-of-One will enable QIAGEN to significantly expand its ...

Elevated hormone flags liver problems in mice with methylmalonic acidemia

Study findings can immediately be applied to human patients with the disease

11-Dec-2018 - Researchers have discovered that a hormone, fibroblast growth factor 21 (FGF21), is extremely elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia (MMA), a serious genomic disorder. Based on this finding, medical teams treating patients with ...

New drug candidates reverse drug resistance in multiple myeloma in preclinical models

31-Oct-2018 - In an article Medical University of South Carolina investigators report that a new compound enhances the efficacy of proteasome inhibitors (PIs), the standard-of-care for the treatment of multiple myeloma (MM), in cell culture and in preclinical models. The efficacy and safety of the novel ...

CureVac enters clinical phase with mRNA vaccine

First data expected on intramuscular application of the newly developed vaccine

25-Oct-2018 - CureVac AG, a fully integrated biopharmaceutical company pioneering the field of mRNA-based drugs, today announced the initiation of its Phase I dose-escalation clinical trial with the novel mRNA-based rabies vaccine, CV7202. This is the first-in-human clinical trial of CureVac’s naturally ...

Who won the Nobel Prize for Physiology or Medicine and for which research?

01-Oct-2018 - The Nobel Prize for Physiology or Medicine focuses on the research on cancer immunotherapies. Two pioneers in this field were awarded for their almost life-long research in this area. The laureates James P. Allison Born in 1948 the scientists worked at several famous and major cancer research ...

Combining antibiotics changes their effectiveness

06-Jul-2018 - The effectiveness of antibiotics can be altered by combining them with each other, non-antibiotic drugs or even with food additives. Depending on the bacterial species, some combinations stop antibiotics from working to their full potential whilst others begin to defeat antibiotic resistance, ...

New tool analyzes disease and drug effects with unprecedented accuracy and consistency

14-May-2018 - A new protein analysis tool developed at the University at Buffalo could vastly increase the speed and precision with which disease and drug effects are analyzed. The groundbreaking tool, called IonStar, is the first to provide near-perfect accuracy when quantifying and comparing the abundance of ...

Fresh insights into light-activated cancer drugs

15-Feb-2018 - Cancer drugs activated by light, minimizing toxic side-effects, are a step closer thanks to new research from University of Warwick and Monash University through the Monash Warwick Alliance Platinum-based chemotherapy drug candidate kills cancer cells in specific targeted areas, and totally ...