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The recipe for making a fruit fly

Scientists use mass spectrometry to determine the absolute copy number of nuclear proteins and histone marks

21-Oct-2019

Currently, most if not all of the proteins that are required for constructing a multicellular organism are known. However, it is largely unclear how many copies of each protein species are present and needed to permit an animal to develop into a complete organism. Researchers at the Max Planck ...

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Lasker Award 2019 for the invention of Herceptin

11-Sep-2019

Herceptin was the first monoclonal antibody that blocks a cancer causing protein. For the invention of Herceptin and the development of a life-saving therapy for women with breast cancer, three researchers are now receiving the Lasker~DeBakey Clinical Medical Research Award: Axel Ullrich, ...

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Breakthrough Prize 2020 for biochemist Hartl and geneticist Horwich

09-Sep-2019

F.-Ulrich Hartl, Director at the Max Planck Institute of Biochemistry in Martinsried, is awarded the Breakthrough Prize in Life Sciences 2020 together with Arthur L. Horwich of Yale School of Medicine/HHMI. They are honored for discovering functions of molecular chaperones in mediating protein ...

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Screening proteins to expose early signs of illness

Matthias Mann named European Inventor Award 2019 finalist

08-May-2019

The European Patent Office (EPO) announces that German physicist, biochemist and bioinformatician Matthias Mann has been nominated for the European Inventor Award 2019 for developing techniques to screen proteins in bulk for the early detection of disease. Named as one of three finalists in the ...

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Access control for proteins

27-Nov-2018

The trans-Golgi network (TGN) is the central hub for the transport of proteins within and out of cells. As protein transport is essential for cell biology, the cell closely regulates which proteins are packaged and transported in vesicles. However, the process by which non-signal-carrying ...

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Decoding the structure of huntingtin

Determining the three dimensional structure of the protein could help to develop new treatments of Huntington's disease

23-Feb-2018

Mutations on a single gene, the huntingtin gene, are the cause of Huntington's disease. They lead to an incorrect form of the correspondent protein. With the help of cryo-electron microscopy researchers from the Max Planck Institute of Biochemistry in Martinsried and Ulm University have now ...

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The future of crop engineering

Scientists want to increase the efficiency of photosynthesis

11-Dec-2017

Photosynthesis is the process underlying all plant growth. Scientists aim to boost photosynthesis to meet the increasing global demand for food by engineering its key enzyme Rubisco. Now, researchers at the Max Planck Institute of Biochemistry have succeeded in producing functional plant Rubisco ...

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Cellular power outage

Quality control in the mitochondria

01-Nov-2017

A common feature of neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease are deposits of aggregated proteins in the patient's cells that cause damage to cellular functions. Scientists report that, even in normal cells, aberrant aggregation-prone proteins are ...

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The pyrenoid is a carbon-fixing liquid droplet

26-Sep-2017

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. However, Rubisco performs this reaction slowly and can also have unwanted reactions with oxygen. Algae have figured out a clever way to increase the efficiency of carbon ...

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Molecular Force Sensors

21-Sep-2017

Proteins are often considered as molecular machines. To understand how they work, it is not enough to visualize the involved proteins under the microscope. Wherever machines are at work mechanical forces occur, which in turn influence biological processes. These extremely small intracellular ...

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