New method accelerates resistance testing in urinary tract infections

Targeted therapy instead of broad-spectrum antibiotics

06-Jan-2026 - Researchers at the Technical University of Munich (TUM) have developed a method for diagnosing urinary tract infections that significantly accelerates antibiotic resistance testing in urine. Because the procedure does not require labor-intensive pre-cultivation of bacteria – as is standard ...

Start-up dedicated to developing new antibiotics

Smartbax nominated for Falling Walls award

06-Nov-2023 - It all began with basic research: While conducting laboratory experiments, a team at the Technical University of Munich (TUM) came across an active agent against multidrug-resistant bacteria with a fundamental difference to antibiotics developed to date. The researchers have since established a ...

Cell-free production of bacteriophages

Viruses help combat antibiotic-resistant bacteria

01-Aug-2022 - More and more bacteria are becoming resistant to antibiotics. Bacteriophages are one alternative in the fight against bacteria: These viruses attack very particular bacteria in a highly specific way. Now a Munich research team has developed a new way to produce bacteriophages efficiently and ...

Designed bacteria produce coral-antibiotic

Sustainable biotechnological production of a natural substance against tuberculosis

19-Aug-2020 - Corals growing on the reefs of the Bahamas produce an active agent that kills multi-resistant tuberculosis bacteria. Scientists at the Technical University of Munich (TUM) have managed to produce the antibiotic biotechnologically in the laboratory – fast, cost-efficient and sustainably. Thomas ...

Grow faster, die sooner

How growth rates influence the fitness of bacteria: Antibiotic therapy with a carrot and a stick?

10-Aug-2020 - Bacteria are survival artists: When they get nutrition, they multiply rapidly, albeit they can also survive periods of hunger. But, when they grow too quickly, their ability to survive is hampered, as studies by a research team at the Technical University of Munich (TUM) on E. coli bacteria show. ...

From cancer medication to antibiotic

Modified cancer drug effective against multi-resistant bacteria

18-Dec-2019 - Antibiotic-resistant bacteria are increasingly the source of deadly infections. A team of scientists from the Technical University of Munich (TUM) and the Helmholtz Center for Infection Research (HZI) in Braunschweig have now modified an approved cancer drug to develop an active agent against ...

ClpX-ClpP protein complex could be starting point for new antibiotics

Weak spot in pathogenic bacteria

08-Oct-2019 - Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of “ammunition” because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key ...

Double strike against tuberculosis

Beta-lactone inhibits mycomenbrane biosynthesis and potentiates antibiotics

02-Jan-2018 - In search of new strategies against life-threatening tuberculosis infections, a team from the Technical University of Munich (TUM), as well as Harvard University and Texas A&M University in the USA have found a new ally. They discovered a substance that interferes with the mycomembrane formation ...

Neutrons help to determine enzyme function

New point of attack against stomach bacterium Helicobacter pylori

21-Dec-2016 - There is a strong suspicion that Helicobacter pylori is linked to the development of stomach cancer. Now an international team of researchers led by Prof. Donald R. Ronning (University of Toledo, USA) has used neutrons to unlock the secret to the functionality of an important enzyme in the ...

Sucessful Spin-Out of ImevaX GmbH from the Technische Universität München

17-Oct-2014 - ImevaX GmbH commenced its research and development activities in their own premises in Munich on Sep. 1st, 2014. With this step, ImevaX realized a successful spin-out from the Technische Universität München (TUM). A key factor for the success of the founder Professor Markus Gerhard and his team, ...